CAJ | 학술논문

目的：观察不同浓度和溶媒对胺碘酮输液中不溶性微粒的变化，为临床合理用药提供参考。方法将注射用盐酸胺碘酮分别注入5％葡萄糖注射液和0．9％氯化钠注射液中配成2．4mg? mL －1和6mg? mL －1的输液，测定输液的不溶性微粒数及观察输液的外观变化。结果将胺碘酮加入5％葡萄糖注射液配成浓度为2．4mg? mL －1的输液测得不溶性微粒数较少，而加入5％葡萄糖注射液中配成浓度为6．0mg? mL －1的输液测得不溶性微粒数明显增加；加入0．9％氯化钠注射液配成浓度为2．4mg? mL －1的输液外观浑浊。结论注射用盐酸胺碘酮的5％葡萄糖输液不溶性微粒数随浓度的升高而增加，注射用盐酸胺碘酮配伍时不宜使用0．9％的氯化钠注射为溶媒。
목적：관찰불동농도화용매대알전동수액중불용성미립적변화，위림상합리용약제공삼고。방법장주사용염산알전동분별주입5％포도당주사액화0．9％록화납주사액중배성2．4mg? mL －1화6mg? mL －1적수액，측정수액적불용성미립수급관찰수액적외관변화。결과장알전동가입5％포도당주사액배성농도위2．4mg? mL －1적수액측득불용성미립수교소，이가입5％포도당주사액중배성농도위6．0mg? mL －1적수액측득불용성미립수명현증가；가입0．9％록화납주사액배성농도위2．4mg? mL －1적수액외관혼탁。결론주사용염산알전동적5％포도당수액불용성미립수수농도적승고이증가，주사용염산알전동배오시불의사용0．9％적록화납주사위용매。
OBJECTIVE To observe the changes of insoluble particles in different concentrations and solvent amiodaroneinfusion,provideareferenceforclinicalmedication.METHODS 5%glucoseinjectionor0.9%sodi-um chloride injection was used to prepare amiodarone into 2.4mg? mL-1 and 6mg? mL-1 infusion,the determination of the insoluble particles in the infusion and observation of changes in appearance of the infusion.RESULTS Injec-tion 2.4mg? mL-1 amiodarone hydrochloride infusion prepared by 5%glucose injection had smaller number of insol-uble particles.The number 6 mg? mL-1 amiodarone infasion prepared by 5% glucose injection had significant in-creased insoluble particles.Amiodarone hydrochloride injection prepared by 0.9%sodium chloride injection became turbid solution.CONCLUSION Injection of amiodarone hydrochloride in 5% glucose infusion insoluble particle number increased with increasing concentration,0.9%sodium chloride injection should not be used with amiodarone hydrochloride.