北京生物医学工程
北京生物醫學工程
북경생물의학공정
BEIJING BIOMEDICAL ENGINEERING
2015年
4期
379-382
,共4页
于钟德%李平%肖灵%訾蕊%费兴波
于鐘德%李平%肖靈%訾蕊%費興波
우종덕%리평%초령%자예%비흥파
刺激脉宽%电刺激%电诱发复合动作电位
刺激脈寬%電刺激%電誘髮複閤動作電位
자격맥관%전자격%전유발복합동작전위
stimulating pulse width%electrical stimulation%electrically evoked compound action potential
目的:研究脉宽阈值积与刺激脉宽之间的关系,深化对电刺激听神经反应的认识。方法首先,根据已有的单根听神经刺激脉宽与阈值之间的表达式和电诱发复合动作电位( electrically evoked compound action potential,ECAP)刺激脉宽与阈值之间的表达式,推导出脉宽阈值积与刺激脉宽之间成线性关系。其次,利用 Shepherd 发布的实验数据与豚鼠实验数据进行研究,发现脉宽阈值积与脉宽的关系不能用简单的线性关系进行解释,其曲线中存在极值点。结果研究结果表明,由于实验结果中脉宽阈值积与刺激脉宽之间呈现较强的非线性特性,因此由刺激脉宽与阈值之间的关系式推导出的脉宽阈值积与脉宽之间的关系式与实验结果不符。结论需进一步研究刺激脉宽对听神经反应的影响,给出符合实验结果的表达式。
目的:研究脈寬閾值積與刺激脈寬之間的關繫,深化對電刺激聽神經反應的認識。方法首先,根據已有的單根聽神經刺激脈寬與閾值之間的錶達式和電誘髮複閤動作電位( electrically evoked compound action potential,ECAP)刺激脈寬與閾值之間的錶達式,推導齣脈寬閾值積與刺激脈寬之間成線性關繫。其次,利用 Shepherd 髮佈的實驗數據與豚鼠實驗數據進行研究,髮現脈寬閾值積與脈寬的關繫不能用簡單的線性關繫進行解釋,其麯線中存在極值點。結果研究結果錶明,由于實驗結果中脈寬閾值積與刺激脈寬之間呈現較彊的非線性特性,因此由刺激脈寬與閾值之間的關繫式推導齣的脈寬閾值積與脈寬之間的關繫式與實驗結果不符。結論需進一步研究刺激脈寬對聽神經反應的影響,給齣符閤實驗結果的錶達式。
목적:연구맥관역치적여자격맥관지간적관계,심화대전자격은신경반응적인식。방법수선,근거이유적단근은신경자격맥관여역치지간적표체식화전유발복합동작전위( electrically evoked compound action potential,ECAP)자격맥관여역치지간적표체식,추도출맥관역치적여자격맥관지간성선성관계。기차,이용 Shepherd 발포적실험수거여돈서실험수거진행연구,발현맥관역치적여맥관적관계불능용간단적선성관계진행해석,기곡선중존재겁치점。결과연구결과표명,유우실험결과중맥관역치적여자격맥관지간정현교강적비선성특성,인차유자격맥관여역치지간적관계식추도출적맥관역치적여맥관지간적관계식여실험결과불부。결론수진일보연구자격맥관대은신경반응적영향,급출부합실험결과적표체식。
Objective To discuss the relationship between stimulating pulse width and the product of pulse width and current threshold. Methods First,based on the expression about pulse width and the current threshold of single nerve and electrically evoked compound action potential( ECAP ),the expression which describes the relationship between pulse width and the product of pulse width and the current threshold is derived. The result shows that the relationship between them is linear. Second,judging from the results of Shepherd and animal experiment,the linear relationship can not precisely express the relationship between them,because there is an extreme point on their relation curve. Results Research result shows that,because of the non-linearity of the experiment results,there are some discrepancy between the experiment results and the expression which is derived from the expression about pulse width and the current threshold. Conclusions Because of the discrepancy and the nonlinearity of experiment results,we should further discuss the influence of electrical stimuli on auditory nerve and propose an accurate expression.