CAJ | 학술논문

目的：探讨心脏瓣膜置换同期行心房颤动双极射频消融术血清白细胞介素-6（IL-6）和几丁质酶-3样蛋白-1（YKL-40）水平表达的变化。方法：选择2013年1月-2014年1月安徽医科大学第二附属医院手术成功转复的心脏瓣膜病合并房颤患者58例（房颤组），心脏瓣膜病58例（瓣膜组），于患者入院后第2天、术后30天、术后180天清晨空腹抽取肘静脉血3m L，分离血清，采用酶联免疫吸附法(ELISA)测定血清IL-6和YKL-40水平。结果：房颤组患者术前血清IL-6，YKL-40（3.05±2.76mg/L，3.71±0.62ug/L）明显高于瓣膜组患者（1.49±1.07mg/L，2.80±0.54ug/L）（P=0.000，P=0.000）。房颤组患者血清YKL-40在术后30天（3.05±0.57ug/L），术后180天（2.96±0.61u g/L）较术前（3.71±0.62u g/L）明显下降（P=0.000，P=0.000）。房颤组患者血清Y K L-40在术后180天（2.96±0.61ug/L）较术后30天（3.05±0.57ug/L）无明显变化（P=0.421）。瓣膜组及房颤组患者血清IL-6在术后30天（3.65±2.63ug/L，4.51±2.83mg/L）较术前（1.49±1.07ug/L，3.05±2.76mg/L）上升(P=0.000，P=0.000)，在术后180天（1.43±1.32ug/L，1.78±1.21mg/L）较术后30天又明显下降(P=0.000，P=0.000)。房颤组患者术后180天血清I L-6较术前明显下降（P=0.000）。结论：血清Y K L-40及IL-6与房颤关系密切，房颤射频消融成功转复后患者血清IL-6和YKL-40水平下降。
목적：탐토심장판막치환동기행심방전동쌍겁사빈소융술혈청백세포개소-6（IL-6）화궤정질매-3양단백-1（YKL-40）수평표체적변화。방법：선택2013년1월-2014년1월안휘의과대학제이부속의원수술성공전복적심장판막병합병방전환자58례（방전조），심장판막병58례（판막조），우환자입원후제2천、술후30천、술후180천청신공복추취주정맥혈3m L，분리혈청，채용매련면역흡부법(ELISA)측정혈청IL-6화YKL-40수평。결과：방전조환자술전혈청IL-6，YKL-40（3.05±2.76mg/L，3.71±0.62ug/L）명현고우판막조환자（1.49±1.07mg/L，2.80±0.54ug/L）（P=0.000，P=0.000）。방전조환자혈청YKL-40재술후30천（3.05±0.57ug/L），술후180천（2.96±0.61u g/L）교술전（3.71±0.62u g/L）명현하강（P=0.000，P=0.000）。방전조환자혈청Y K L-40재술후180천（2.96±0.61ug/L）교술후30천（3.05±0.57ug/L）무명현변화（P=0.421）。판막조급방전조환자혈청IL-6재술후30천（3.65±2.63ug/L，4.51±2.83mg/L）교술전（1.49±1.07ug/L，3.05±2.76mg/L）상승(P=0.000，P=0.000)，재술후180천（1.43±1.32ug/L，1.78±1.21mg/L）교술후30천우명현하강(P=0.000，P=0.000)。방전조환자술후180천혈청I L-6교술전명현하강（P=0.000）。결론：혈청Y K L-40급IL-6여방전관계밀절，방전사빈소융성공전복후환자혈청IL-6화YKL-40수평하강。
Objective; Explore heart valve replacement in the same period line bipolar radiofrequency ablation of atrial fibrillation serum interleukin 6 (IL - 6), and protein chitinase - 3 samples - 1 (YKL 40) level changes in the expression.MethodsChoice in January 2013 - January 2014 anhui medical university second affiliated hospital surgery success converting heart valve disease combined 58 patients with atrial fibrillation (af), 58 cases of heart valve disease group (valves), in patients admitted to hospital after 2 days, 30 days after operation, postoperative 180 days early in the morning on an empty stomach pumping elbow 3 ml, venous blood serum separation, USES the method of enzyme-linked immunosorbent (ELISA) determination of serum IL - 6 and YKL 40 levels. Results Atrial fibrillation patients preoperative serum IL - 6, YKL 40 - (3.05 + / - 2.76 mg/L, 3.71 + / - 0.62 ug/L) is significantly higher than valve group of patients (1.49 + / - 1.07 mg/L, 2.80 + / - 0.54 ug/L) (P = 0.000,P = 0.000). Atrial fibrillation patients serum YKL 40-30 days after surgery (3.05 + / - 0.57 ug/L), after 180 days (2.96 + / - 0.61 ug/L) compared with preoperative (3.71+ / - 0.62 ug/L) significantly decreased (P= 0.000,P= 0.000). Atrial fibrillation patients serum YKL 40-180 days after surgery (2.96 + / - 0.61 ug/L) is 30 days postoperatively (3.05 + / - 0.57 ug/L) no significant change (P = 0.421).ConclusionsSerum YKL 40 and IL - 6 - closely associated with atrial fibrillation, atrial fibrillation after radiofrequency ablation successfully converting patients serum IL - 6 and YKL 40 levels drop.