CAJ | 학술논문

在辅助生殖技术（assisted reproduction technique，ART）周期中，控制性超促排卵及取卵后容易导致黄体功能不全，为了解决这个问题，常规需要在ART周期中进行黄体支持（luteal phase support，LPS）。目前疗效肯定的LPS方案是单独或者联合使用不同剂量孕激素和人绒毛膜促性腺激素（human chorionic gonadotropin，hCG），但hCG会增加卵巢过度刺激综合征（ovarian hyperstimulation syndrome，OHSS）发生的风险。近年来有学者发现在LPS中添加促性腺激素释放激素激动剂（gonadotropin-releasing hormone agonist， GnRHa）不仅可减少OHSS的发生，还能获得良好的妊娠结局。虽然如此，目前有关GnRHa使用剂型、剂量、给药途径、时间、机制和效果仍不清楚，尚需进一步探索。
재보조생식기술（assisted reproduction technique，ART）주기중，공제성초촉배란급취란후용역도치황체공능불전，위료해결저개문제，상규수요재ART주기중진행황체지지（luteal phase support，LPS）。목전료효긍정적LPS방안시단독혹자연합사용불동제량잉격소화인융모막촉성선격소（human chorionic gonadotropin，hCG），단hCG회증가란소과도자격종합정（ovarian hyperstimulation syndrome，OHSS）발생적풍험。근년래유학자발현재LPS중첨가촉성선격소석방격소격동제（gonadotropin-releasing hormone agonist， GnRHa）불부가감소OHSS적발생，환능획득량호적임신결국。수연여차，목전유관GnRHa사용제형、제량、급약도경、시간、궤제화효과잉불청초，상수진일보탐색。
The luteal phase defect frequently occurs after the controlled ovarian stimulation and follicular aspiration in assisted reproduction techniques (ARTs). As a clinical routine, luteal phase support (LPS) is recommended in ART cycles. The LPS treatment with definite curative effect is progesterone alone or progesterone plus hCG. However, hCG is associated with the increased risk of OHSS. Recently, it was showed that the added GnRH agonist in LPS treatment could decrease the OHSS risk, but also improve the outcomes of pregnancy. It is necessary to explore further the formulation of GnRH agonist, the minimal effective dose and the most effective timing and protocol, as well as its exact mechanism.