CAJ | 학술논문

缺血组织恢复血流后，组织损伤程度急剧增加，免疫反应是缺血／再灌注造成组织二次损伤的关键因素之一。Th1／Th2在正常机体中处于免疫平衡状态，在缺血／再灌注环境下，易发生 Th1／Th2漂移，形成 Th1优势状态，介导细胞免疫。过度的免疫反应即可引起细胞凋亡和组织损伤。研究发现，诱导 Th1优势状态向 Th2优势状态转化，是治疗缺血／再灌注损伤的可行途径。随着多组分、多靶点的现代药物研发模式的兴起，中药在治疗复杂疾病中的优势凸显。该文从Th1／Th2失衡与缺血／再灌注损伤关系及中药在该疾病中的应用前景进行了综述。
결혈조직회복혈류후，조직손상정도급극증가，면역반응시결혈／재관주조성조직이차손상적관건인소지일。Th1／Th2재정상궤체중처우면역평형상태，재결혈／재관주배경하，역발생 Th1／Th2표이，형성 Th1우세상태，개도세포면역。과도적면역반응즉가인기세포조망화조직손상。연구발현，유도 Th1우세상태향 Th2우세상태전화，시치료결혈／재관주손상적가행도경。수착다조분、다파점적현대약물연발모식적흥기，중약재치료복잡질병중적우세철현。해문종Th1／Th2실형여결혈／재관주손상관계급중약재해질병중적응용전경진행료종술。
The damage of tissue increases dramatically after reperfusion of blood supply to ischemic tissues.Immune response is one of the key reasons of ischemia-reperfusion injury.Th1 /Th2 generally stays balanced in normal states.Under the envi-ronment of ischemia reperfusion,Th1 /Th2 shifting let Th1 domi-nant to mediate cellular immunity.Excessive immune reaction may cause cell apoptosis and tissue damage.Recent studies showed that induction of transferring Th1 dominant to Th2 domi-nant was feasible for the treatment of ischemia-reperfusion inju-ry.With the progress of modern drug development paradigm“multi-composition,multi-target”,Chinese medicine has advan-tages in treating complex diseases.This paper summarizes the research of the relationship between Th1 /Th2 imbalance and is-chemia-reperfusion injury,together with the prospects of tradi-tional Chinese medicine with multi-target effect in ischemia-reperfusion injury.