国际生殖健康/计划生育杂志
國際生殖健康/計劃生育雜誌
국제생식건강/계화생육잡지
JOURNLA OF INTERNATIONAL REPRODUCTIVE HEALTH/FAMILY PLANNING
2015年
5期
420-423
,共4页
哺乳动物雷帕霉素靶蛋白%信号传导%精子发生%塞尔托利细胞%血睾屏障
哺乳動物雷帕黴素靶蛋白%信號傳導%精子髮生%塞爾託利細胞%血睪屏障
포유동물뢰파매소파단백%신호전도%정자발생%새이탁리세포%혈고병장
Mammalian target of rapamycin%Signal transduction%Spermatogenesis%Sertoli cells%Blood-testis barrier
哺乳动物雷帕霉素靶蛋白(mammalian target of rapamycin,mTOR)是磷脂酰肌醇激酶相关激酶家族的一员,是一种高度保守的丝/苏氨酸蛋白激酶。其参与调节蛋白质合成、能量代谢和氧化应激等多项生理功能,在细胞增殖、生长、分化过程中起着中心调控的作用。近年许多研究证实在哺乳动物睾丸中mTOR信号通路可以促进支持细胞(sertoli cell)增殖与分化;mTOR信号通路不仅调控血-睾屏障(blood-testis barrier)的形成,而且mTORC1与mTORC2分别调节血-睾屏障的开放与闭合;在精子发生(spermatogenesis)过程中,mTOR信号通路调控精原干细胞的增殖分化与自我更新,且调控着精母细胞的减数分裂。因此,mTOR信号通路在哺乳动物睾丸中具有重要的调控作用。综述mTOR信号通路在睾丸中对支持细胞增殖分化、血-睾屏障形成和精子发生的调控作用。
哺乳動物雷帕黴素靶蛋白(mammalian target of rapamycin,mTOR)是燐脂酰肌醇激酶相關激酶傢族的一員,是一種高度保守的絲/囌氨痠蛋白激酶。其參與調節蛋白質閤成、能量代謝和氧化應激等多項生理功能,在細胞增殖、生長、分化過程中起著中心調控的作用。近年許多研究證實在哺乳動物睪汍中mTOR信號通路可以促進支持細胞(sertoli cell)增殖與分化;mTOR信號通路不僅調控血-睪屏障(blood-testis barrier)的形成,而且mTORC1與mTORC2分彆調節血-睪屏障的開放與閉閤;在精子髮生(spermatogenesis)過程中,mTOR信號通路調控精原榦細胞的增殖分化與自我更新,且調控著精母細胞的減數分裂。因此,mTOR信號通路在哺乳動物睪汍中具有重要的調控作用。綜述mTOR信號通路在睪汍中對支持細胞增殖分化、血-睪屏障形成和精子髮生的調控作用。
포유동물뢰파매소파단백(mammalian target of rapamycin,mTOR)시린지선기순격매상관격매가족적일원,시일충고도보수적사/소안산단백격매。기삼여조절단백질합성、능량대사화양화응격등다항생리공능,재세포증식、생장、분화과정중기착중심조공적작용。근년허다연구증실재포유동물고환중mTOR신호통로가이촉진지지세포(sertoli cell)증식여분화;mTOR신호통로불부조공혈-고병장(blood-testis barrier)적형성,이차mTORC1여mTORC2분별조절혈-고병장적개방여폐합;재정자발생(spermatogenesis)과정중,mTOR신호통로조공정원간세포적증식분화여자아경신,차조공착정모세포적감수분렬。인차,mTOR신호통로재포유동물고환중구유중요적조공작용。종술mTOR신호통로재고환중대지지세포증식분화、혈-고병장형성화정자발생적조공작용。
Mammalian target of rapamycin (mTOR), one member of the family of phosphatidylinositol kinase, is a kind of highly conservative Ser/Thr protein kinase. It regulates many physiological functions, such as protein synthesis,metabolism and oxidative stress,which plays an important role in cell proliferation,growth and differentiation. It was confirmed that mTOR signaling pathway can regulate the proliferation and differentiation of Sertoli cell. The mTOR signaling pathway regulates the formation of blood-testis barrier ,but also mTORC1 and mTORC2 respectively regulate the lock and open of blood-testis barrier. The mTOR pathway regulates proliferation and self-renewal of spermatogenia stem cell,and the meiosis of spermatocyte in the process of spermatogenesis. The review discussed the effects of mTOR signaling pathway in regulating the proliferation of sertoli cell,the formation of blood-testis barrier and spermatogenesis.