CAJ | 학술논문

哺乳动物卵母细胞减数分裂成熟过程中存在3个重要时期：第一次减数分裂前期的双线期停滞，第一次减数分裂向第二次减数分裂的转变，第二次减数分裂中期阻滞。该过程复杂，丝裂原激活蛋白激酶、成熟促进因子、Septin蛋白、突触结合蛋白1、Rec8蛋白等多种已知或未知的蛋白参与其中，从细胞周期调节、纺锤体组装调节、染色体分离调节等3方面调控卵母细胞减数分裂成熟。综述这一过程中相关蛋白的表达规律、亚细胞定位及相互作用，着重描述了这些蛋白在哺乳动物卵母细胞减数分裂成熟中的可能作用及机制。
포유동물란모세포감수분렬성숙과정중존재3개중요시기：제일차감수분렬전기적쌍선기정체，제일차감수분렬향제이차감수분렬적전변，제이차감수분렬중기조체。해과정복잡，사렬원격활단백격매、성숙촉진인자、Septin단백、돌촉결합단백1、Rec8단백등다충이지혹미지적단백삼여기중，종세포주기조절、방추체조장조절、염색체분리조절등3방면조공란모세포감수분렬성숙。종술저일과정중상관단백적표체규률、아세포정위급상호작용，착중묘술료저사단백재포유동물란모세포감수분렬성숙중적가능작용급궤제。
The meiosis and maturation of mammalian oocyte include three important periods: arresting at diplotene of the first meiotic prophase ,entering into the second round of meiosis and arresting at metaphase of the second meiosis. This complicated process is controlled by a series of factors, known or unknown factors ,such as mitogen-activated protein kinase,maturation promoting factor,Septin,Synaptotagmin 1,Rec8 and so on. They regulate the meiotic maturation of mammalian oocyte in the following three aspects: cell cycle ,spindle assembly and chromosome segregation. This paper reviewed the expression pattern, subcellular locatization and interaction of those proteins or factors, and their potential functions and mechanisms during the meiotic maturation of mammalian oocyte.