CAJ | 학술논문

梓醇是一种环烯醚萜类化合物，具有广泛的药理活性，包括抗脑缺血损伤、抗老年性痴呆、抗炎、抑制毛细血管通透性、止痛、抗肿瘤、缓泻、降血糖、保肝及抗衰老等多种药理作用。该文总结了目前梓醇研究所涉及的信号通路，包括：NF-κB 信号通路、PI3K／AKT 信号通路、BDNF／TrkB 信号通路、JAK2／STAT3血管新生信号通路、MAPK 信号通路、TGF-β／Smad 信号通路、乙酰胆碱信号通路等，以此加深对梓醇分子信号机制的理解和认识，为梓醇后续深入研究提供参考。
재순시일충배희미첩류화합물，구유엄범적약리활성，포괄항뇌결혈손상、항노년성치태、항염、억제모세혈관통투성、지통、항종류、완사、강혈당、보간급항쇠로등다충약리작용。해문총결료목전재순연구소섭급적신호통로，포괄：NF-κB 신호통로、PI3K／AKT 신호통로、BDNF／TrkB 신호통로、JAK2／STAT3혈관신생신호통로、MAPK 신호통로、TGF-β／Smad 신호통로、을선담감신호통로등，이차가심대재순분자신호궤제적리해화인식，위재순후속심입연구제공삼고。
Catalpol is a kind of iridoid,which has wide pharma-cological activities,including anti-cerebral ischemia,improving senile dementia,anti-inflammation,inhibiting capillary permea-bility,relieving pain,anti-tumor,antidiarrheal,reducing blood sugar level,protecting liver,and anti-aging.The mechanisms of Catalpol effects have been well studied.Signaling pathways in-clude NF-κB signaling pathway,PI3K/AKT signaling pathway, BDNF /TrkB signaling pathway,JAK2 /STAT3 /angiogenesis sig-naling pathway,MAPK signaling pathway,TGF-β/Smad signa-ling pathway,and ACh signaling pathway.We reviewed related signaling pathways of Catalpol effects,in order to broaden the understanding of molecular mechanism and signaling pathways of Catalpol,to know the status of catalpol,and to provide new di-rection to study Catalpol.