国际生殖健康/计划生育杂志
國際生殖健康/計劃生育雜誌
국제생식건강/계화생육잡지
JOURNLA OF INTERNATIONAL REPRODUCTIVE HEALTH/FAMILY PLANNING
2015年
5期
375-378
,共4页
徐琰琪%吕品%陈秀娟
徐琰琪%呂品%陳秀娟
서염기%려품%진수연
不育,女(雌)性%结核%受精,体外%胚胎移植%流产,自然
不育,女(雌)性%結覈%受精,體外%胚胎移植%流產,自然
불육,녀(자)성%결핵%수정,체외%배태이식%유산,자연
Infertility,female%Tuberculosis%Fertilization in vitro%Embryo transfer%Abortion,spontaneous
目的:探讨潜伏性结核在体外受精-胚胎移植(IVF-ET)妊娠后发作的特点,及在输卵管性原发不孕患者助孕治疗前检查及治疗潜伏性结核的必要性。方法:回顾性分析2012年1月—2014年12月在内蒙古医科大学附属医院生殖中心经IVF-ET助孕妊娠后因结核流产的6例患者的资料。结果:6例患者均为临床妊娠,均因结核发病而流产。6例患者皮肤结核菌素实验或干扰素γ释放试验阳性。其中,仅1例既往有结核病史,其余既往及检查均未提示有活动性结核。最终确诊子宫内膜结核3例;子宫内膜结核合并肺结核1例;脑膜结核1例;肺结核1例。且潜伏性结核发作导致流产的患者流产后需要抗结核治疗至少1年后再次妊娠。结论:潜伏性结核感染者妊娠后可能发病,且发病后妊娠结局较差。
目的:探討潛伏性結覈在體外受精-胚胎移植(IVF-ET)妊娠後髮作的特點,及在輸卵管性原髮不孕患者助孕治療前檢查及治療潛伏性結覈的必要性。方法:迴顧性分析2012年1月—2014年12月在內矇古醫科大學附屬醫院生殖中心經IVF-ET助孕妊娠後因結覈流產的6例患者的資料。結果:6例患者均為臨床妊娠,均因結覈髮病而流產。6例患者皮膚結覈菌素實驗或榦擾素γ釋放試驗暘性。其中,僅1例既往有結覈病史,其餘既往及檢查均未提示有活動性結覈。最終確診子宮內膜結覈3例;子宮內膜結覈閤併肺結覈1例;腦膜結覈1例;肺結覈1例。且潛伏性結覈髮作導緻流產的患者流產後需要抗結覈治療至少1年後再次妊娠。結論:潛伏性結覈感染者妊娠後可能髮病,且髮病後妊娠結跼較差。
목적:탐토잠복성결핵재체외수정-배태이식(IVF-ET)임신후발작적특점,급재수란관성원발불잉환자조잉치료전검사급치료잠복성결핵적필요성。방법:회고성분석2012년1월—2014년12월재내몽고의과대학부속의원생식중심경IVF-ET조잉임신후인결핵유산적6례환자적자료。결과:6례환자균위림상임신,균인결핵발병이유산。6례환자피부결핵균소실험혹간우소γ석방시험양성。기중,부1례기왕유결핵병사,기여기왕급검사균미제시유활동성결핵。최종학진자궁내막결핵3례;자궁내막결핵합병폐결핵1례;뇌막결핵1례;폐결핵1례。차잠복성결핵발작도치유산적환자유산후수요항결핵치료지소1년후재차임신。결론:잠복성결핵감염자임신후가능발병,차발병후임신결국교차。
Objective: To discuss the clinical characteristics of the activated latent tuberculosis in those pregnant women after in vitro fertilization-embryo transfer (IVF-ET), and to explore the necessity of examination and treatment before assisted reproduction in oviduct primary infertility. Methods:Six cases of abortion in IVF-ET pregnant women, due to activated genital tuberculosis, were retrospectively reviewed, from 2012 January to 2014 December in our reproductive center. Results:Six cases were clinical pregnant, had abortion operation due to the re-activated latent tuberculosis. Tuberculin skin test (TST)/interferon-gamma release assays (IGRAs) was positive in all of 6 cases. Only one patient had a history of tuberculosis. There were not any findings of active tuberculosis in their medical examination. The final diagnoses of 6 cases were as follows, 3 cases with endometrial tuberculosis, 1 case with endometrial and pulmonary tuberculosis, 1 case with meningeal tuberculosis, 1 case with pulmonary tuberculosis. All those abortion patients due to the activated latent tuberculosis were treated by antituberculosis at least one year before next pregnancy. Conclusions:The latent tuberculosis could be re-activated after pregnancy, and the pregnant outcome be poor, which provide us the important information that the latent tuberculosis should be diagnosed and treated exactly in those infertility women before IVF-ET.