CAJ | 학술논문

目的：通过结构方程建模对影响体外受精/胞浆内单精子注射（IVF/ICSI）治疗结局的生理及心理因素进行探索。方法：随机选取442例符合纳入条件的患者，填写状态-特质焦虑量表（STAI）、贝克抑郁量表（BDI）、领悟社会支持量表（PSSS）及医学应对方式问卷（MCMQ），同时收集所有患者的社会人口学资料、疾病基础状况及治疗情况等，进行相关分析并建立结构方程模型。结果：胚胎质量、负性心理因素对妊娠结局有直接影响，年龄、基础卵泡刺激素（bFSH）、基础窦卵泡数（AFC）、获卵数、促性腺激素（Gn）启动剂量、Gn使用总量、Gn使用时间对妊娠结局有间接影响。结论：患者生理及心理因素之间存在复杂相关关系，除生物学因素的改善，消除负性心理因素后对改善妊娠结局有一定作用。
목적：통과결구방정건모대영향체외수정/포장내단정자주사（IVF/ICSI）치료결국적생리급심리인소진행탐색。방법：수궤선취442례부합납입조건적환자，전사상태-특질초필량표（STAI）、패극억욱량표（BDI）、령오사회지지량표（PSSS）급의학응대방식문권（MCMQ），동시수집소유환자적사회인구학자료、질병기출상황급치료정황등，진행상관분석병건립결구방정모형。결과：배태질량、부성심리인소대임신결국유직접영향，년령、기출란포자격소（bFSH）、기출두란포수（AFC）、획란수、촉성선격소（Gn）계동제량、Gn사용총량、Gn사용시간대임신결국유간접영향。결론：환자생리급심리인소지간존재복잡상관관계，제생물학인소적개선，소제부성심리인소후대개선임신결국유일정작용。
Objective: To clarify the effect of psychological and physiological factors on IVF/ICSI outcomes by developing a structural equation model. Methods:442 infertility women who met the inclusion criteria were selected randomly as subjects. Psychological questionnaires (STAI, BDI, PSSS and MCMQ) were used to measure psychological status. Data of social demography, basic disease and treatment were also collected. Basic statistical analysis was conducted by SPSS 16.0, and the structural equation model was developed by AMOS20.0. Results:Through the structural equation modeling, we found that the quality of embryos and the psychological states directly influenced the clinical pregnancy outcomes. Age, bFSH, AFC, the number of retrieved oocyte, Gn starting dose, the treatment duration and total dose of Gn indirectly affected the pregnancy outcomes. Conclusions:The crossover effect between psychological and physiological factors were complicated. It is helpful for improving the pregnancy outcomes to remove the negative psychological factors, besides improving biological factors.