CAJ | 학술논문

卵巢早衰（POF）目前尚无有效的治疗手段，采用间充质干细胞（MSCs）移植治疗 POF 取得了一定的效果。MSCs 因其具有低免疫原性、可移植性、组织修复能力强等特征，目前被认为对于多种疾病的治疗具有重要的研究价值。基质细胞衍生因子-1（SDF-1）及其受体 CXC chemokine receptor 4（CXCR4）组成的 SDF-1／CXCR4轴在MSCs 迁移中起重要作用，可否通过调控 SDF-1／CXCR4诱导 MSCs 的归巢至卵巢而最大程度地发挥 POF 的临床治疗作用？本文就 MSCs 的归巢调控机制及在 POF 中的研究作一综述，以期为其应用于 POF 的治疗提供理论依据。
란소조쇠（POF）목전상무유효적치료수단，채용간충질간세포（MSCs）이식치료 POF 취득료일정적효과。MSCs 인기구유저면역원성、가이식성、조직수복능력강등특정，목전피인위대우다충질병적치료구유중요적연구개치。기질세포연생인자-1（SDF-1）급기수체 CXC chemokine receptor 4（CXCR4）조성적 SDF-1／CXCR4축재MSCs 천이중기중요작용，가부통과조공 SDF-1／CXCR4유도 MSCs 적귀소지란소이최대정도지발휘 POF 적림상치료작용？본문취 MSCs 적귀소조공궤제급재 POF 중적연구작일종술，이기위기응용우 POF 적치료제공이론의거。
Premature ovarian failure (POF)causes serious damage to mental and physical health in middle-aged women,especially in childbearing-aged women.However,there is currently no effective treatment for POF.In recent years,the transplantation of mesenchymal stem cells (MSCs)has been considered as the effective treatment for POF.MSCs have characteristics of low immunogenicity,transferability and strong tissue repair capacity.Therefore,MSCs have important value in the treatment of many diseases.Stromal cell derived factor-1(SDF-1)and its cognate re-ceptor CXC chemokine receptor 4(CXCR4)play an important role in the migration of MSCs.The induction of homing of MSCs to ovary by regulating SDF-1/CXCR4 may exert the curative effect on POF to greatest extent.In this paper,we review the regulation mechanism of homing of MSCs to provide theoretical basis for the application of MSCs in the treatment POF.