CAJ | 학술논문

目的：探讨不同的红细胞制品输注治疗儿童重型地中海贫血的不良反应。方法将68例重型地中海贫血患儿按治疗方法的不同分为 A 组、B 组、C 组和 D 组，每组17例。A 组输注普通红细胞，B 组输注洗涤红细胞，C 组输注年轻红细胞，D 组输注去白红细胞。比较4组不良反应[非溶血性发热性输血反应（FNHTR）和免疫介导的输血不良反应、输血传播的感染及输血性铁过载]发生率。结果4组均未发生输血传播的感染。C、D 2组 FNHTR和免疫介导的输血不良反应、输血性铁过载发生率均明显低于 A、B 2组（均 P ＜0．05）。结论年轻红细胞输注和去白红细胞输注治疗儿童重型地中海贫血能够降低感染及不良反应的发生率，对去铁治疗有促进作用，值得临床上进一步推荐和应用。
목적：탐토불동적홍세포제품수주치료인동중형지중해빈혈적불량반응。방법장68례중형지중해빈혈환인안치료방법적불동분위 A 조、B 조、C 조화 D 조，매조17례。A 조수주보통홍세포，B 조수주세조홍세포，C 조수주년경홍세포，D 조수주거백홍세포。비교4조불량반응[비용혈성발열성수혈반응（FNHTR）화면역개도적수혈불량반응、수혈전파적감염급수혈성철과재]발생솔。결과4조균미발생수혈전파적감염。C、D 2조 FNHTR화면역개도적수혈불량반응、수혈성철과재발생솔균명현저우 A、B 2조（균 P ＜0．05）。결론년경홍세포수주화거백홍세포수주치료인동중형지중해빈혈능구강저감염급불량반응적발생솔，대거철치료유촉진작용，치득림상상진일보추천화응용。
Objective To investigate the adverse reactions of infusion of different types of red cell products in children with severe thalassemia.Methods A total of 68 children with severe thalassemia were treated with the infusion of normal red blood cells(group A,n=17),washed red blood cells(group B,n=17),young red blood cells(group C,n=17)or leukocyte-poor red blood cells(group D,n=17).The incidences of febrile non-hemolytic transfusion reactions(FNHTR), immune-mediated adverse reactions,transfusion-transmitted infections and transfusion iron over-load were compared among the four groups.Results No patients had transfusion-transmitted in-fections in all the four groups.The incidences of FNHTR,immune-mediated adverse reactions and transfusion iron overload in group C and D were significantly lower than those in group A and B (P <0.05).Conclusion The transfusion of young red blood cells or leukocyte-poor red blood cells which can reduce the incidences of infections and complications in children with severe thalassemia and improve the efficacy of iron treatment.Therefore,it is worthy of further recom-mendation and application.