实用临床医学
實用臨床醫學
실용림상의학
Practical Clinical Medicine
2015年
7期
21-23
,共3页
杨慎先%王磊%李慧娟%蔡海羽
楊慎先%王磊%李慧娟%蔡海羽
양신선%왕뢰%리혜연%채해우
原发性高血压%核因子κB%血管紧张素Ⅱ%早期肾损害
原髮性高血壓%覈因子κB%血管緊張素Ⅱ%早期腎損害
원발성고혈압%핵인자κB%혈관긴장소Ⅱ%조기신손해
essential hypertension%nuclear factor-kappa B%angiotensinⅡ%early renal dysfunction
目的:探讨血清核因子κB (NF-κB)、血管紧张素Ⅱ(AngⅡ)水平与原发性高血压(EH)早期肾损害之间的关系。方法入选96例原发性高血压患者,另选取同期50例健康体检者做为对照组。采用放射免疫分析法测定尿微量白蛋白(mALB)水平,根据 mALB 水平将入选高血压患者分为高血压伴肾损害组(A 组)56例和高血压不伴肾损害组(B 组)40例;同时采用酶联免疫吸附法(ELISA)测定血清 NF-κB、AngⅡ水平。结果A 组和 B 组血清NF-κB、AngⅡ水平明显高于正常对照组,差异有统计学意义(P <0.05);与 B 组比较,A 组血清 NF-κB、AngⅡ水平明显更高,差异有统计学意义(P <0.05)。直线相关分析显示,血清 NF-κB 水平与收缩压、舒张压、mALB 呈正相关(r=0.381、0.473、0.346,均 P <0.05);血清 AngⅡ水平与收缩压、舒张压、mALB 呈正相关(r =0.507、0.431、0.375,均 P <0.05)。结论EH 患者血清 NF-κB、AngⅡ水平明显升高,EH 伴早期肾损害患者更明显,提示 NF-κB、AngⅡ可能参与了原发性高血压及其合并早期肾功能损害的发生发展。
目的:探討血清覈因子κB (NF-κB)、血管緊張素Ⅱ(AngⅡ)水平與原髮性高血壓(EH)早期腎損害之間的關繫。方法入選96例原髮性高血壓患者,另選取同期50例健康體檢者做為對照組。採用放射免疫分析法測定尿微量白蛋白(mALB)水平,根據 mALB 水平將入選高血壓患者分為高血壓伴腎損害組(A 組)56例和高血壓不伴腎損害組(B 組)40例;同時採用酶聯免疫吸附法(ELISA)測定血清 NF-κB、AngⅡ水平。結果A 組和 B 組血清NF-κB、AngⅡ水平明顯高于正常對照組,差異有統計學意義(P <0.05);與 B 組比較,A 組血清 NF-κB、AngⅡ水平明顯更高,差異有統計學意義(P <0.05)。直線相關分析顯示,血清 NF-κB 水平與收縮壓、舒張壓、mALB 呈正相關(r=0.381、0.473、0.346,均 P <0.05);血清 AngⅡ水平與收縮壓、舒張壓、mALB 呈正相關(r =0.507、0.431、0.375,均 P <0.05)。結論EH 患者血清 NF-κB、AngⅡ水平明顯升高,EH 伴早期腎損害患者更明顯,提示 NF-κB、AngⅡ可能參與瞭原髮性高血壓及其閤併早期腎功能損害的髮生髮展。
목적:탐토혈청핵인자κB (NF-κB)、혈관긴장소Ⅱ(AngⅡ)수평여원발성고혈압(EH)조기신손해지간적관계。방법입선96례원발성고혈압환자,령선취동기50례건강체검자주위대조조。채용방사면역분석법측정뇨미량백단백(mALB)수평,근거 mALB 수평장입선고혈압환자분위고혈압반신손해조(A 조)56례화고혈압불반신손해조(B 조)40례;동시채용매련면역흡부법(ELISA)측정혈청 NF-κB、AngⅡ수평。결과A 조화 B 조혈청NF-κB、AngⅡ수평명현고우정상대조조,차이유통계학의의(P <0.05);여 B 조비교,A 조혈청 NF-κB、AngⅡ수평명현경고,차이유통계학의의(P <0.05)。직선상관분석현시,혈청 NF-κB 수평여수축압、서장압、mALB 정정상관(r=0.381、0.473、0.346,균 P <0.05);혈청 AngⅡ수평여수축압、서장압、mALB 정정상관(r =0.507、0.431、0.375,균 P <0.05)。결론EH 환자혈청 NF-κB、AngⅡ수평명현승고,EH 반조기신손해환자경명현,제시 NF-κB、AngⅡ가능삼여료원발성고혈압급기합병조기신공능손해적발생발전。
Objective To investigate the relationships between serum nuclear factor-kappa B (NF-κB)and angiotensinⅡ(AngⅡ)levels and early renal damage in patients with essential hy-pertension (EH).Methods The levels of urinary microalbumin (mALB)were measured by ra-dioimmunoassay and levels of NF-κB and AngⅡ were determined by ELISA in 96 patients with EH and 50 healthy controls.According to the levels of mALB,these EH patients were divided in-to two groups:group A (56 patients with renal damage)and group B (40 patients without renal damage).Results Compared with healthy controls,serum NF-κB and AngⅡ levels significantly increased in patients with EH (P <0.05).Compared with group B,serum NF-κB and AngⅡ lev-els significantly increased in group A (P < 0.05).The systolic blood pressure,diastolic blood pressure and mALB levels were positively correlated with serum NF-κB levels (r=0.381,0.473 and 0.346,respectively;P <0.05),as well as with serum AngⅡ levels (r = 0.507,0.431 and 0.375,respectively;P <0.05).Conclusion Serum NF-κB and AngⅡ levels obviously increase in patients with EH,especially in patients with early renal damage,suggesting that NF-κB and AngⅡ may be involved in the occurrence and development of EH complicated by early renal damage.