CAJ | 학술논문

目的：探讨糖尿病患者肺部组织病理特征，为临床研究提供参考。方法：选择行肺部肿块切除术的56例患者作为研究对象，分成两组，其中一组为糖尿病组，一组为非糖尿病组，各28例。观察两组肺部组织显微及超微结构，并分析转化生长因子（TGF-β1）及肺泡表面活性蛋白（SP-A）、晚期糖基化终末产物（AGEs）的差异。结果：糖尿病组患者在光镜下可见肺组织有胶原纤维增生，电镜下可见细胞质内，有线粒体基质溶解，及嵴大部分发生溶解，毛细血管内皮基底膜未见增厚，肺部组织SP-A表达要显著低于非糖尿病组患者，但TGF-β1与AGEs有增加，统计学差异明显（P＜0.05）。结论：糖尿病患者肺部组织病理改变有其独特性，肺部是糖尿病损伤中的靶器官。
목적：탐토당뇨병환자폐부조직병리특정，위림상연구제공삼고。방법：선택행폐부종괴절제술적56례환자작위연구대상，분성량조，기중일조위당뇨병조，일조위비당뇨병조，각28례。관찰량조폐부조직현미급초미결구，병분석전화생장인자（TGF-β1）급폐포표면활성단백（SP-A）、만기당기화종말산물（AGEs）적차이。결과：당뇨병조환자재광경하가견폐조직유효원섬유증생，전경하가견세포질내，유선립체기질용해，급척대부분발생용해，모세혈관내피기저막미견증후，폐부조직SP-A표체요현저저우비당뇨병조환자，단TGF-β1여AGEs유증가，통계학차이명현（P＜0.05）。결론：당뇨병환자폐부조직병리개변유기독특성，폐부시당뇨병손상중적파기관。
Objective To explore the pathological features of lung tissue in patients with diabetes, to provide reference for clinical research. Method To Choose OK lung tumor resection 56 patients as research subjects, divided into two groups, one group for the diabetic group, a group of non-diabetic group, 28 cases each. Lung tissue were observed microscopic and ultrastructural, and analyze the difference of transforming growth factor (TGF-β1) and pulmonary surfactant proteins (SP-A), advanced glycation end products (AGEs) in. Result Diabetes patients can be seen in the light microscope has collagen fibers in lung tissue, electron microscope, the cytoplasm, mitochondria matrix dissolution, and the crest most dissolves, no capillary endothelial basement membrane thickening, SP-A expression in lung tissue To significantly lower than non-diabetic patients, but TGF-β1 and AGEs have increased statistically significantly different (P<0.05). Conclusion Pathological changes in the lungs of patients with diabetes is unique, diabetes, lung is a target organ injury.