医药前沿
醫藥前沿
의약전연
YIAYAO QIANYAN
2015年
23期
5-5,6
,共2页
抑郁症%LNC2%小胶质细胞
抑鬱癥%LNC2%小膠質細胞
억욱증%LNC2%소효질세포
Depression%LNC2%Microglia
目前，抑郁症的机制研究热点之一是炎症反应又称为细胞因子假说，近年来，越来越多的研究表明炎症反应过程及小胶质细胞过度活化参与抑郁症的病理过程。L C N2能够激活小胶质细胞的M1途径。因此，L C N2可能通过促进小胶质细胞的激活，从而在抑郁症的发病过程中起作用，为治疗抑郁症拓展了新的思路。
目前，抑鬱癥的機製研究熱點之一是炎癥反應又稱為細胞因子假說，近年來，越來越多的研究錶明炎癥反應過程及小膠質細胞過度活化參與抑鬱癥的病理過程。L C N2能夠激活小膠質細胞的M1途徑。因此，L C N2可能通過促進小膠質細胞的激活，從而在抑鬱癥的髮病過程中起作用，為治療抑鬱癥拓展瞭新的思路。
목전，억욱증적궤제연구열점지일시염증반응우칭위세포인자가설，근년래，월래월다적연구표명염증반응과정급소효질세포과도활화삼여억욱증적병리과정。L C N2능구격활소효질세포적M1도경。인차，L C N2가능통과촉진소효질세포적격활，종이재억욱증적발병과정중기작용，위치료억욱증탁전료신적사로。
At present, one of the hot topics in the study of the mechanism of depression, is inflammation, also known as cytokines hypothesis. In recent years, more and more studies have shown that inflammatory reaction process and excessive activation of microglia, involved in the pathological process of depression. M1 way of LCN2 can activate microglia. LCN2 may, therefore, by promoting the activation of microglia, thus play a role in the process of the onset of depression, expanding its new train of thought for the treatment of depression.
