中国现代医药杂志
中國現代醫藥雜誌
중국현대의약잡지
MODERN MEDICINE JOURNAL OF CHINA
2015年
8期
47-49
,共3页
宫颈非典型鳞状细胞%高危型人乳头状瘤病毒%分流
宮頸非典型鱗狀細胞%高危型人乳頭狀瘤病毒%分流
궁경비전형린상세포%고위형인유두상류병독%분류
Atypical squamous cells%High-risk human papillomavirus%Triage
目的：探讨高危型人乳头状瘤病毒（hr-HPV DNA）检测对意义不明确的宫颈非典型鳞状细胞（ASC-US）患者临床处理的指导意义。方法经宫颈液基薄层细胞学检查（TCT）诊断为ASC-US的197例患者分别行hr-HPV DNA检测及阴道镜下活检，分析hr-HPV感染阳性组与阴性组中鳞状上皮病变有无差异，hr-HPV DNA检测对鳞状上皮病变的预测价值。结果 hr-HPV DNA 检测对ASC-US中鳞状上皮病变发现的敏感度，特异度，阳性预测值，阴性预测值分别为86.4%，75.2%，50.0%，95.1%。阳性组与阴性组中鳞状上皮病变的发生率为50.0%和5.0%，差异有统计学意义（P<0.05）。结论 hr-HPV DNA检测对ASC-US病例的进一步处理有指导分流作用，hr-HPV DNA阳性组可进一步行阴道镜下活检， hr-HPV DNA阴性组可于一段时间后复查宫颈细胞学。
目的：探討高危型人乳頭狀瘤病毒（hr-HPV DNA）檢測對意義不明確的宮頸非典型鱗狀細胞（ASC-US）患者臨床處理的指導意義。方法經宮頸液基薄層細胞學檢查（TCT）診斷為ASC-US的197例患者分彆行hr-HPV DNA檢測及陰道鏡下活檢，分析hr-HPV感染暘性組與陰性組中鱗狀上皮病變有無差異，hr-HPV DNA檢測對鱗狀上皮病變的預測價值。結果 hr-HPV DNA 檢測對ASC-US中鱗狀上皮病變髮現的敏感度，特異度，暘性預測值，陰性預測值分彆為86.4%，75.2%，50.0%，95.1%。暘性組與陰性組中鱗狀上皮病變的髮生率為50.0%和5.0%，差異有統計學意義（P<0.05）。結論 hr-HPV DNA檢測對ASC-US病例的進一步處理有指導分流作用，hr-HPV DNA暘性組可進一步行陰道鏡下活檢， hr-HPV DNA陰性組可于一段時間後複查宮頸細胞學。
목적：탐토고위형인유두상류병독（hr-HPV DNA）검측대의의불명학적궁경비전형린상세포（ASC-US）환자림상처리적지도의의。방법경궁경액기박층세포학검사（TCT）진단위ASC-US적197례환자분별행hr-HPV DNA검측급음도경하활검，분석hr-HPV감염양성조여음성조중린상상피병변유무차이，hr-HPV DNA검측대린상상피병변적예측개치。결과 hr-HPV DNA 검측대ASC-US중린상상피병변발현적민감도，특이도，양성예측치，음성예측치분별위86.4%，75.2%，50.0%，95.1%。양성조여음성조중린상상피병변적발생솔위50.0%화5.0%，차이유통계학의의（P<0.05）。결론 hr-HPV DNA검측대ASC-US병례적진일보처리유지도분류작용，hr-HPV DNA양성조가진일보행음도경하활검， hr-HPV DNA음성조가우일단시간후복사궁경세포학。
Objective To evaluate the use of the high-risk human papillomavirus (hr-HPV) DNA test in the further clinical management of women with atypical squamous cells of undetermined significance (ASC-US). Methods 197 women diagnosed as ASC-US by liquid-based thinprep cytology test (TCT) underwent the hr-HPV DNA test (the hybrid capture 2, HCⅡ) and colposcopic-directed cervical biopsy respectively. Analyzed difference of squamous intraepithelial lesion (SIL) and squamous cell carcinoma (SCC) between the hr-HPV positive group and the hr-HPV negative group. Assessed predictive value of screening cervical SIL or SCC by the hr-HPV DNA test. Results The ratio of SIL and SCC in the hr-HPV positive group was 50%and obviously higher than that of hr-HPV negative group (P<0.05). In detecting SIL and SCC by hr-HPV DNA test, the sensitivity, specificity, positive predictive value and negative predictive value were 86.4%, 75.2%, 50.0%, 95.1%. Con-clusion The hr-HPV test plays an important role in triaging ASC-US. Colposcopic-directed biopsy is the next step to evaluate cervix with positive hr-HPV test. Repeating TCT is adopted for cervix with negative hr-HPV test.
