CAJ | 학술논문

目的探讨年度间收缩压变异性的分布情况及其主要影响因素.方法采用前瞻性队列研究设计,以开滦研究中同时参加过2006年6月至2007年10月、2008年6月至2009年10月、2010年6月至2011年10月、2012年6月至2013年10月4次查体的开滦集团职工作为研究对象.收缩压变异性定义为收缩压标准差(SSD)和变异系数(SCV).采用多因素线性回归分析不同指标对SSD和SCV的影响.结果 (1)完成4次查体并且血压资料完整的职工共43 360例(男性32 959例,女性10 401例),年龄(48.2±11.5)岁.总人群的SSD和SCV均值分别为10.91 mmHg(1 mmHg=0.133 kPa)和8.34％.不论男性还是女性,SSD和SCV均随着年龄的增长而增大(P均＜0.001).(2)多因素线性回归分析显示:SSD的影响因素包括收缩压(β=0.225,P＜0.001)、年龄(β=0.163,P ＜0.001)、空腹血糖(β=0.038,P＜0.001)、服用降压药(β=0.038,P＜0.001)、性别(β=0.038,P＜0.001)、吸烟(β=0.025,P＜0.001)、饮酒(β=-0.022,P＜0.001)、经常锻炼(β=-0.018,P=0.001)、高敏C反应蛋白(β=0.016,P=0.001)和体质指数(β=-0.011,P=0.018);SCV的影响因素包括年龄(β =0.139,P＜0.001)、性别(β=0.055,P＜0.001)、收缩压(β=0.047,P＜0.001)、空腹血糖(β=0.033,P＜0.001)、饮酒(β=-0.030,P＜0.001)、体质指数(β=-0.026,P＜0.001)、服用降压药(β=0.026,P＜0.001)、吸烟(β=0.024,P＜0.001)、经常锻炼(β=-0.015,P=0.001)和高敏C反应蛋白(β=0.014,P=0.001).结论 SSD、SCV随着年龄增长而增大.SSD的影响因素主要有收缩压、年龄、空腹血糖、服用降压药、性别、吸烟、饮酒、经常锻炼、高敏C反应蛋白和体质指数;SCV的影响因素主要有年龄、性别、收缩压、空腹血糖、饮酒、体质指数、服用降压药、吸烟、经常锻炼和超敏C反应蛋白.
목적 탐토년도간수축압변이성적분포정황급기주요영향인소.방법 채용전첨성대렬연구설계,이개란연구중동시삼가과2006년6월지2007년10월、2008년6월지2009년10월、2010년6월지2011년10월、2012년6월지2013년10월4차사체적개란집단직공작위연구대상.수축압변이성정의위수축압표준차(SSD)화변이계수(SCV).채용다인소선성회귀분석불동지표대SSD화SCV적영향.결과 (1)완성4차사체병차혈압자료완정적직공공43 360례(남성32 959례,녀성10 401례),년령(48.2±11.5)세.총인군적SSD화SCV균치분별위10.91 mmHg(1 mmHg=0.133 kPa)화8.34％.불론남성환시녀성,SSD화SCV균수착년령적증장이증대(P균＜0.001).(2)다인소선성회귀분석현시:SSD적영향인소포괄수축압(β=0.225,P＜0.001)、년령(β=0.163,P ＜0.001)、공복혈당(β=0.038,P＜0.001)、복용강압약(β=0.038,P＜0.001)、성별(β=0.038,P＜0.001)、흡연(β=0.025,P＜0.001)、음주(β=-0.022,P＜0.001)、경상단련(β=-0.018,P=0.001)、고민C반응단백(β=0.016,P=0.001)화체질지수(β=-0.011,P=0.018);SCV적영향인소포괄년령(β =0.139,P＜0.001)、성별(β=0.055,P＜0.001)、수축압(β=0.047,P＜0.001)、공복혈당(β=0.033,P＜0.001)、음주(β=-0.030,P＜0.001)、체질지수(β=-0.026,P＜0.001)、복용강압약(β=0.026,P＜0.001)、흡연(β=0.024,P＜0.001)、경상단련(β=-0.015,P=0.001)화고민C반응단백(β=0.014,P=0.001).결론 SSD、SCV수착년령증장이증대.SSD적영향인소주요유수축압、년령、공복혈당、복용강압약、성별、흡연、음주、경상단련、고민C반응단백화체질지수;SCV적영향인소주요유년령、성별、수축압、공복혈당、음주、체질지수、복용강압약、흡연、경상단련화초민C반응단백.
Objective To investigate the distribution and major influencing factors of annual systolic blood pressure variability from a large population cohort.Methods In this prospective cohort study,data from Kailuan Group employees who attended all 4 physical examinations (taken in June 2006 to October 2007,June 2008 to October 2009,June 2010 to October 2011,June 2012 to October 2013,respectively) were analyzed (32 959 males and 10 401 females,mean age:(48.2 ± 11.5) years old).Systolic blood pressure variability was defined as the standard deviation (SSD) and the coefficient of variation(SCV) of systolic blood pressure of 4 physical examinations.Multivariate linear regression analysis was used to determine the related influencing factors of SSD and SCV.Results (1) The mean of SSD and SCV for this cohort was 10.91 mmHg(1 mmHg =0.133 kPa) and 8.34％,respectively.SSD and SCV increased in male and female with increasing age(both P ＜0.001).(2) Multiple linear regression analysis showed that systolic blood pressure (β =0.225,P ＜ 0.001),age (β =0.163,P ＜ 0.001),fasting blood glucose(β =0.038,P ＜ 0.001),the use of anti-hypertensive drugs (β =0.038,P ＜ 0.001),sex (β =0.038,P ＜ 0.001),smoking (β =0.025,P ＜ 0.001),alcohol drinking (β =-0.022,P ＜ 0.001),physical exercise(β =-0.018,P =0.001),high-sensitivity c-reactive protein (β =0.016,P =0.001),body mass index(β =-0.011,P =0.018) were related to SSD.Age (β =0.139,P ＜ 0.001),sex (β =0.055,P ＜0.001),systolic blood pressure(β =0.047,P ＜0.001),fasting blood glucose(β =0.033,P ＜0.001),drinking(β =-0.030,P ＜ 0.001),body mass index (β =-0.026,P ＜ 0.001),the use of anti-hypertensive drugs(β =0.026,P ＜ 0.001),smoking (β =0.024,P ＜ 0.001),physical exercise (β =-0.015,P =0.001),high-sensitivity c-reactive protein (β =0.014,P =0.001) were related to SCV.Conclusions SSD and SCV increase with increasing age.Systolic blood pressure,age,fasting blood glucose,the use of anti-hypertensive drugs,sex,smoking,drinking,physical exercise,high-sensitivity c-reactive protein,body mass index are major influencing factors for SSD.Age,sex,systolic blood pressure,fasting blood glucose,alcohol drinking,body mass index,the use of anti-hypertensive drugs,smoking,physical exercise,high-sensitivity c-reactive protein are major influencing factors for SCV.