中国麻风皮肤病杂志
中國痳風皮膚病雜誌
중국마풍피부병잡지
CHINA JOURNAL OF LEPROSY AND SKIN DISEASES
2015年
9期
551-554
,共4页
TNF-α%IL-17%银屑病
TNF-α%IL-17%銀屑病
TNF-α%IL-17%은설병
TNF-α%IL-17%psoriasis
目的：：检测TNF-α与IL-17在银屑病皮损中的表达。方法： ELISA检测68例银屑病患者与28例对照(非银屑病患者)血清TNF-α和IL-17的表达；免疫印迹法检测局部皮损、患者正常皮肤及对照者皮肤中TNF-α和IL-17的表达；qT-PCR检测TNF-α和IL-17的mRNA表达。结果：银屑病患者血清TNF-α、IL-17的表达均高于对照组( P<0.05)；皮损组织中TNF-α、IL-17蛋白及mRNA的表达均高于患者正常皮肤及对照组皮肤(均P<0.05)。结论： TNF-α与IL-17在银屑病的发展中可能相互作用。
目的：：檢測TNF-α與IL-17在銀屑病皮損中的錶達。方法： ELISA檢測68例銀屑病患者與28例對照(非銀屑病患者)血清TNF-α和IL-17的錶達；免疫印跡法檢測跼部皮損、患者正常皮膚及對照者皮膚中TNF-α和IL-17的錶達；qT-PCR檢測TNF-α和IL-17的mRNA錶達。結果：銀屑病患者血清TNF-α、IL-17的錶達均高于對照組( P<0.05)；皮損組織中TNF-α、IL-17蛋白及mRNA的錶達均高于患者正常皮膚及對照組皮膚(均P<0.05)。結論： TNF-α與IL-17在銀屑病的髮展中可能相互作用。
목적：：검측TNF-α여IL-17재은설병피손중적표체。방법： ELISA검측68례은설병환자여28례대조(비은설병환자)혈청TNF-α화IL-17적표체；면역인적법검측국부피손、환자정상피부급대조자피부중TNF-α화IL-17적표체；qT-PCR검측TNF-α화IL-17적mRNA표체。결과：은설병환자혈청TNF-α、IL-17적표체균고우대조조( P<0.05)；피손조직중TNF-α、IL-17단백급mRNA적표체균고우환자정상피부급대조조피부(균P<0.05)。결론： TNF-α여IL-17재은설병적발전중가능상호작용。
Objective:To detect the expression of TNF-αand IL-17 in the patients with psoriasis. Meth-ods:The serum levels of TNF-α and IL-17 were detected in 68 patients with psoriasis and 28 controls from cosmetic surgery department. The expression of protein TNF-αand IL-17 in the patients’ lesions and normal skin of the patients as well as the skin of normal controls was detected by ELISA and the mRNA of TNF-αand IL-17 was detected by qT-PCR. Results:The levels of serum TNF-αand IL-17 were higher in the patients than in controls. The levels of protein and mRNA expression of TNF-αand IL-17 were higher in the patients’ lesions than in the normal skin of the patients and controls. Conclusion:TNF-αand IL-17 may be interacted in the progress of psoriasis.
