CAJ | 학술논문

目的：探讨肿瘤体积和放疗剂量对局部晚期非小细胞肺癌(NSCLC)三维适形放疗(3D-CRT)预后的影响。方法78例接受3D-CRT的局部晚期NSCLC患者为研究对象,利用三维适形放射计划系统和CT扫描勾画相应靶区,分别定义为GTV-T、GTV-P和GTV-N,分析各靶区肿瘤体积和放疗剂量对3D-CRT的预后效果。结果全组研究对象中肿瘤最大直径<5.00 cm的患者生存率高于肿瘤最大直径≥5.00 cm的患者(P<0.05)；GTV-T<100.00 cm3的患者生存率明显高于GTV-T≥100.00 cm3的患者(P<0.05)。分层分析显示放疗处方剂量≤66 Gy亚组中,肿瘤大体体积越小,生存率越高。结论应用三维适形放射计划系统和CT扫描所勾画的大体肿瘤体积对接受放疗的NSCLC患者长期生存率有显著影响；对体积小的肿瘤行大剂量放疗对局部晚期NSCLC患者的生存有益。
목적：탐토종류체적화방료제량대국부만기비소세포폐암(NSCLC)삼유괄형방료(3D-CRT)예후적영향。방법78례접수3D-CRT적국부만기NSCLC환자위연구대상,이용삼유괄형방사계화계통화CT소묘구화상응파구,분별정의위GTV-T、GTV-P화GTV-N,분석각파구종류체적화방료제량대3D-CRT적예후효과。결과전조연구대상중종류최대직경<5.00 cm적환자생존솔고우종류최대직경≥5.00 cm적환자(P<0.05)；GTV-T<100.00 cm3적환자생존솔명현고우GTV-T≥100.00 cm3적환자(P<0.05)。분층분석현시방료처방제량≤66 Gy아조중,종류대체체적월소,생존솔월고。결론응용삼유괄형방사계화계통화CT소묘소구화적대체종류체적대접수방료적NSCLC환자장기생존솔유현저영향；대체적소적종류행대제량방료대국부만기NSCLC환자적생존유익。
Objective To investigate influence of gross tumor volume and radiotherapy dose on prognosis of three dimensional conformal radiation therapy (3D-CRT) for locally advanced non-small cell lung cancer (NSCLC). Methods There were 78 locally advanced NSCLC patients receiving 3D-CRT as study subjects. Three dimensional conformal radiation planning system and CT screening were applied for delineating corresponding target sections, as GTV-T, GTV-P and GTV-N. Gross tumor volume and radiotherapy dose in each target section were analyzed for their prognosis effects. Results Patients with tumor diameter<5.00 cm had higher survival rate than those with tumor diameter≥5.00 cm (P<0.05). Patients with GTV-T<100.00 cm3 had obviously higher survival rate than those with GTV-T≥100.00 cm3 (P<0.05). Stratification analysis showed that in subgroup with radiotherapy dose ≤66 Gy, the survival rate increased while gross tumor volume declined. Conclusion Gross tumor volume shown by three dimensional conformal radiation planning system and CT screening has remarkable influence on long-term survival rate in NSCLC patients. It is also beneficial for locally advanced NSCLC patients receiving large radiotherapy dose for small tumor volume.