CAJ | 학술논문

目的：探讨依托考昔联合氨基葡萄糖治疗中、重度膝关节骨性关节炎的临床疗效及其临床应用价值。方法将106例中、重度膝关节骨性关节炎患者随机分为对照组（单纯应用依托考昔）和治疗组（依托考昔＋氨基葡萄糖），连续治疗4 w。对两组患者治疗前后 VAS 评分及 Lysholm 评分变化进行统计学分析，并计算其临床总有效率。结果治疗4 w 后，两组患者 VAS 评分较治疗前明显降低，Lysholm 评分均较治疗前明显升高（P 均＜0．05），治疗组的效果优于对照组；对照组总有效率为88．89％，治疗组总有效率为92．30％，差异有统计学意义（P＜0．05）。结论依托考昔联合氨基葡萄糖治疗中、重度膝关节骨性关节炎临床疗效显著，患者疼痛缓解两组VAS 评分相近，改善膝关节功能疗效优于单纯依托考昔。
목적：탐토의탁고석연합안기포도당치료중、중도슬관절골성관절염적림상료효급기림상응용개치。방법장106례중、중도슬관절골성관절염환자수궤분위대조조（단순응용의탁고석）화치료조（의탁고석＋안기포도당），련속치료4 w。대량조환자치료전후 VAS 평분급 Lysholm 평분변화진행통계학분석，병계산기림상총유효솔。결과치료4 w 후，량조환자 VAS 평분교치료전명현강저，Lysholm 평분균교치료전명현승고（P 균＜0．05），치료조적효과우우대조조；대조조총유효솔위88．89％，치료조총유효솔위92．30％，차이유통계학의의（P＜0．05）。결론의탁고석연합안기포도당치료중、중도슬관절골성관절염림상료효현저，환자동통완해량조VAS 평분상근，개선슬관절공능료효우우단순의탁고석。
Objective To observe clinical efficacy and value of Etoricoxib combined with glucosamine treat-ment of moderate to severe knee osteoarthritis.Methods 106 patients with moderate to severe osteoarthri-tis of the knee were randomly divided into control group (simple application of Etoricoxib)and treatment group (Etoricoxib+Glucosamine),continuous treatment 4 weeks.The statistical analysis was applied in the two groups of patients before and after treatment VAS score and Lysholm score changes,and the rates of total clinical effectiveness were calculated.Results After 4 weeks treatment,the two groups were sig-nificantly lower VAS scores,Lysholm score treatment group was significantly better than those of the control group,and the difference was statistically significant (P <0.05).Conclusion It showed that the clinically significant effects in Etoricoxib combined with Glucosamine treatment of moderate to severe knee osteoarthritis,relieve pain similar in both groups of patients,improve the efficacy of knee function better than Etoricoxib.