CAJ | 학술논문

以1-苯甲基-4-哌啶酮合成了4-甲基-N-乙基-N-(4-哌啶基)苯磺酰胺(中间体7)，以4-氯苯甲氯为原料，通过溴化及还原合成了5-溴-2-(4-氯苯甲氧基)溴甲基苯(中间体3)，通过中间体7和中间体3合成了一种新的小分子化合物4-甲基-N-乙基-N-(N-(5-溴-2-(4-氯苯甲基氧基)苯甲基)-4-哌啶基)苯磺酰胺，对该产物进行了1 H NMR、MS、IR 表征及生物活性检测，结果表明该化合物可以作为药物开发的候选化合物。
이1-분갑기-4-고정동합성료4-갑기-N-을기-N-(4-고정기)분광선알(중간체7)，이4-록분갑록위원료，통과추화급환원합성료5-추-2-(4-록분갑양기)추갑기분(중간체3)，통과중간체7화중간체3합성료일충신적소분자화합물4-갑기-N-을기-N-(N-(5-추-2-(4-록분갑기양기)분갑기)-4-고정기)분광선알，대해산물진행료1 H NMR、MS、IR 표정급생물활성검측，결과표명해화합물가이작위약물개발적후선화합물。
Interest in the methylbenzenesulfonamide has been increasing due to pyridine,benzenesulfo-nyl,bromine atom such as active group.The small molecular antagonists can be used as a targeting prepa-ration in the prevention of human HIV-1 infection.4-methyl-N-ethyl-N-(piperidin-4-yl)benzenesulfon-amide(intermediate 7 )was prepared from N-Benzyl-4-piperidone.4-bromo-1-((4-chlorobenzyl)oxy)-2-(bromomethyl)benzene(intermediate 3)was synthesized from 1-chloro-4-(chloromethyl)benzene.Further reaction of 7 with 3 gave a novel compound 4-methyl-N-(1-(5-bromo-2-((4-chlorobenzyl)oxy)benzyl)piper-idin-4-yl)-N-ethylbenzenesulfonamide.The compounds were characterized by 1 H NMR,MS,IR and bioac-tivity.The compound can be used as the candidate compounds for drug development.