CAJ | 학술논문

目的：：比较胺碘酮和决奈达隆抗家兔急性心房颤动的作用差异。方法：以17 Hz刺激频率建立心房颤动模型，观察建立模型前后给予胺碘酮和决奈达隆对家兔心房颤动的抑制作用。结果：经心电图分析，家兔急性心房颤动模型成功率为40.5%，模型建立成功后分别给予胺碘酮(5 mg/kg)和决奈达隆(5 mg/kg)均可以明显抑制房颤的持续时间和降低房颤的发作频率；与胺碘酮相比，决奈达隆抑制作用更强(P<0.05)；胺碘酮预处理后预防房颤的再发作用强于决奈达隆，决奈达隆心室率抑制作用强于胺碘酮。结论：在急性房颤中，胺碘酮与决奈达隆具有相似的抗心房颤动作用，药物疗效有差异。
목적：：비교알전동화결내체륭항가토급성심방전동적작용차이。방법：이17 Hz자격빈솔건립심방전동모형，관찰건립모형전후급여알전동화결내체륭대가토심방전동적억제작용。결과：경심전도분석，가토급성심방전동모형성공솔위40.5%，모형건립성공후분별급여알전동(5 mg/kg)화결내체륭(5 mg/kg)균가이명현억제방전적지속시간화강저방전적발작빈솔；여알전동상비，결내체륭억제작용경강(P<0.05)；알전동예처리후예방방전적재발작용강우결내체륭，결내체륭심실솔억제작용강우알전동。결론：재급성방전중，알전동여결내체륭구유상사적항심방전동작용，약물료효유차이。
Objective To compare the different efficacy of amiodarome and dronedarone in treating acute atrial fibrillation. Methods: Acute atrial fibrillation model was induced by rapid atrial pacing with stimulus frequency of 17Hz. Results The successful rate of atrial fibrillation model was about 40.5%. Amiodarone and dronedarone both significantly decreased the duration and occurrence frequence of atrial fibrillation .Compared with amiodarone, dronedarone produced more potent efficacy for preventing atrial fibrillation. Amiodarone pretreatment was superior to dronedarone pretreatment in preventing atrial fibrillation recurrence. Ventricuiar rate decreased more significantly by dronedarone than by amiodarone. Conclusion In acute atrial fibrillation,amiodarone and dronedarone have similar antiarrhythmic effect with different efficacy.