新疆医科大学学报
新疆醫科大學學報
신강의과대학학보
JOURNAL OF XINJIANG MEDICAL UNIVERSITY
2015年
9期
1072-1075
,共4页
王珊姗%木胡牙提%杨玉春%何鹏义%刘志强%卢武红
王珊姍%木鬍牙提%楊玉春%何鵬義%劉誌彊%盧武紅
왕산산%목호아제%양옥춘%하붕의%류지강%로무홍
心房颤动%民族%eNOS%基因多态性
心房顫動%民族%eNOS%基因多態性
심방전동%민족%eNOS%기인다태성
atrial fibrillation%nation%eNOS%gene polymorphism
目的:探讨内皮型一氧化氮合酶基因 T-786C(eNOS T-786C)多态性与新疆地区维吾尔族心房颤动(房颤)患者的关系。方法选取新疆医科大学第一附属医院综合心脏内科收住的维吾尔族非瓣膜性房颤患者100例作为房颤组,维吾尔族非房颤患者100例作为对照组,收集样本,提取外周血 DNA,运用聚合酶链反应(PCR)方法及 DNA 测序进行多态性检测,并对突变位点进行定位及鉴定。结果房颤组年龄、低密度脂蛋白明显高于对照组(P <0.001)。房颤组与对照组样本 eNOS T-786C 基因多态性基因型符合哈迪-温伯格(Hardy-weinberg)平衡(房颤组χ2=2.72,P =0.26;对照组χ2=2.87,P =0.24);房颤组 eNOS T-786C 基因 TT、TC、CC基因型频率分别为0.80(80/100)、0.17(17/100)和0.03(3/100),对照组分别为0.76(76/100)、0.20(20/100)和0.04(4/100),两组基因型分布差异无统计学意义(P >0.05)。房颤组 C 等位基因频率(0.115)与对照组(0.140)差异无统计学意义(P >0.05)。结论新疆地区维吾尔族心房颤动的发生与 eNOS T-786C 多态性无明显相关性。
目的:探討內皮型一氧化氮閤酶基因 T-786C(eNOS T-786C)多態性與新疆地區維吾爾族心房顫動(房顫)患者的關繫。方法選取新疆醫科大學第一附屬醫院綜閤心髒內科收住的維吾爾族非瓣膜性房顫患者100例作為房顫組,維吾爾族非房顫患者100例作為對照組,收集樣本,提取外週血 DNA,運用聚閤酶鏈反應(PCR)方法及 DNA 測序進行多態性檢測,併對突變位點進行定位及鑒定。結果房顫組年齡、低密度脂蛋白明顯高于對照組(P <0.001)。房顫組與對照組樣本 eNOS T-786C 基因多態性基因型符閤哈迪-溫伯格(Hardy-weinberg)平衡(房顫組χ2=2.72,P =0.26;對照組χ2=2.87,P =0.24);房顫組 eNOS T-786C 基因 TT、TC、CC基因型頻率分彆為0.80(80/100)、0.17(17/100)和0.03(3/100),對照組分彆為0.76(76/100)、0.20(20/100)和0.04(4/100),兩組基因型分佈差異無統計學意義(P >0.05)。房顫組 C 等位基因頻率(0.115)與對照組(0.140)差異無統計學意義(P >0.05)。結論新疆地區維吾爾族心房顫動的髮生與 eNOS T-786C 多態性無明顯相關性。
목적:탐토내피형일양화담합매기인 T-786C(eNOS T-786C)다태성여신강지구유오이족심방전동(방전)환자적관계。방법선취신강의과대학제일부속의원종합심장내과수주적유오이족비판막성방전환자100례작위방전조,유오이족비방전환자100례작위대조조,수집양본,제취외주혈 DNA,운용취합매련반응(PCR)방법급 DNA 측서진행다태성검측,병대돌변위점진행정위급감정。결과방전조년령、저밀도지단백명현고우대조조(P <0.001)。방전조여대조조양본 eNOS T-786C 기인다태성기인형부합합적-온백격(Hardy-weinberg)평형(방전조χ2=2.72,P =0.26;대조조χ2=2.87,P =0.24);방전조 eNOS T-786C 기인 TT、TC、CC기인형빈솔분별위0.80(80/100)、0.17(17/100)화0.03(3/100),대조조분별위0.76(76/100)、0.20(20/100)화0.04(4/100),량조기인형분포차이무통계학의의(P >0.05)。방전조 C 등위기인빈솔(0.115)여대조조(0.140)차이무통계학의의(P >0.05)。결론신강지구유오이족심방전동적발생여 eNOS T-786C 다태성무명현상관성。
Objective To investigate the relationship between endothelial nitric oxide synthase gene T-786C polymorphism and atrial fibrillation(AF)in Uyghur patients in Xinjiang.Methods 100 cases of Uyghur patients with non valvular atrial fibrillation (NVAF)were selected as AF case group,100 cases of non at-rial fibrillation patients as the control group,DNA samples was extracted from the peripheral blood,using polymerase chain reaction (PCR)method and DNA sequencing to detect the polymorphism,localization and identification of mutations.All experimental data were statistically analyzed.Results The age and low density lipoprotein cholesterol (LDL-C)in AF group was significantly higher than that in control group (P< 0.001 ).eNOS T-786C polymorphism genotypes in AF group and control group sample was in the balance of Hardy-Weinberg (AF group χ2 =2.72,P =0.26;control group χ2 =2.87,P =0.24).eNOS gene T786C,TT,TC CC genotype frequency in atrial fibrillation group was 0.80 (80/100),0.17 (17/100) and 0.03 (3/100),respectively,in the control group was 0.76 (76/100),0.20 (20/100)and 0.04 (4/100), respectively.Genotype distribution of the two groups have no statistical significance (P >0.05).There was no significant difference between the C allele frequency (0.115)and the control group (0.140)(P >0.05). Conclusion Endothelial nitric oxide synthase gene T-786C polymorphism was not have a quite significant correlation in Uyghur atrial fibrillation in Xinjiang.