CAJ | 학술논문

探索滁菊挥发油微囊的最佳制备工艺。采用复凝聚法制备滁菊挥发油微囊，以外观形态、粒径、包封率、载药量为指标，正交设计优选工艺条件。滁菊挥发油微囊的最佳制备工艺条件为：复合胶与挥发油的比例为1：1，温度为55℃，pH为4.0，固化剂量为1.5mL。制得的滁菊挥发油微囊形态呈圆形、光滑，粒径分布在80~120μm，平均包封率为（48.89±5.93）%，平均载药量为（13.11±2.30）%，TLC 法显示供试品溶液与对照品溶液在相同的位置出现相同斑点。该制备方法操作简单易行，处方合理，制得微囊外观圆整，载药量和包封率较高。
탐색저국휘발유미낭적최가제비공예。채용복응취법제비저국휘발유미낭，이외관형태、립경、포봉솔、재약량위지표，정교설계우선공예조건。저국휘발유미낭적최가제비공예조건위：복합효여휘발유적비례위1：1，온도위55℃，pH위4.0，고화제량위1.5mL。제득적저국휘발유미낭형태정원형、광활，립경분포재80~120μm，평균포봉솔위（48.89±5.93）%，평균재약량위（13.11±2.30）%，TLC 법현시공시품용액여대조품용액재상동적위치출현상동반점。해제비방법조작간단역행，처방합리，제득미낭외관원정，재약량화포봉솔교고。
This paper is to study the preparation microcapsules of volatile oil from Chrysanthemum morifolium Ra-mat. The microcapsules were prepared by complex coacervation with formulation,diameter,amount of the drug and encapsulation efficiency as evaluation index and the preparation was optimized by orthogonal experimental design. The best technology is that compound plastic and the volatile oil of the ratio is 1:1,the temperature is 55℃,pH 4. 0 and formaldehyde in an amount of 1. 5 mL. the prepared microcapsules spherical with smooth surface,and the proportion with a diameter of 80-120μm,encapsulation efficiency was(48. 89 ± 5. 93)%,and the average drug loadings were(13. 11 ± 2. 30)%,TLC indication that the test solution and reference solution appeared at the same spot in the same location. The preparation process is simple and feasible,and the methods of evaluation are reliable. The microcapsules’appearance is round and normal. The drug loading and the encap-sulation efficiency are higher.