医学研究生学报
醫學研究生學報
의학연구생학보
JOURNAL OF MEDICAL POSTGRADUATE
2015年
9期
973-977
,共5页
沈思钰(综述)%傅晓东%王文健(审校)
瀋思鈺(綜述)%傅曉東%王文健(審校)
침사옥(종술)%부효동%왕문건(심교)
中枢神经系统狼疮%神经精神狼疮%系统性红斑狼疮%神经免疫学%神经影像学%目标治疗
中樞神經繫統狼瘡%神經精神狼瘡%繫統性紅斑狼瘡%神經免疫學%神經影像學%目標治療
중추신경계통랑창%신경정신랑창%계통성홍반랑창%신경면역학%신경영상학%목표치료
Central nervous system lupus%Neuropsychiatric lupus%Systemic lupus erythematosus%Neuroimmunology%Neu-roimaging%Treat-to-target
中枢神经系统受累是神经精神狼疮最常见的损害。文中在文献回顾的基础上，重点分析中枢神经系统狼疮的临床表现、发病机制、诊断和治疗，随着神经免疫学、神经影像学及临床治疗学的进展，早期诊断、积极评估及目标治疗可以明显控制发作、改善生存质量及提高预期寿命。未来的方向将可能更关注于患者的临床注册、疾病活动性评价及难治性病例干预的研究。
中樞神經繫統受纍是神經精神狼瘡最常見的損害。文中在文獻迴顧的基礎上，重點分析中樞神經繫統狼瘡的臨床錶現、髮病機製、診斷和治療，隨著神經免疫學、神經影像學及臨床治療學的進展，早期診斷、積極評估及目標治療可以明顯控製髮作、改善生存質量及提高預期壽命。未來的方嚮將可能更關註于患者的臨床註冊、疾病活動性評價及難治性病例榦預的研究。
중추신경계통수루시신경정신랑창최상견적손해。문중재문헌회고적기출상，중점분석중추신경계통랑창적림상표현、발병궤제、진단화치료，수착신경면역학、신경영상학급림상치료학적진전，조기진단、적겁평고급목표치료가이명현공제발작、개선생존질량급제고예기수명。미래적방향장가능경관주우환자적림상주책、질병활동성평개급난치성병례간예적연구。
At present, central nervous system involvement is the most common in neuropsychiatric lupus.This article discus-ses the research status of central nervous system lupus in the past few years which include characteristics of clinical presentation, etio-pathological mechanism, neuroimaging diagnosis and therapeutic strategy.Actually, the advanced technology, especially neuroimmu-nology and neuroimaging, in combination with early diagnosis, effective assessment and treat to target strategy could decrease global disease activity, ameliorate quality of life and increase life expectancy.Furthermore, the prospective researches should be paid more attention in lupus registries, neuropsychiatric questionnaires, damage index and improvement of severe refractory cases in clinic.
