CAJ | 학술논문

目的：探讨吸毒男性梅毒感染者 CD4＋CD25＋调节性 T 细胞表达情况及其影响因素。方法测定144例吸毒男性梅毒感染者、41例吸毒男性非梅毒感染者、35例男性单纯梅毒感染者和35名健康男性的 CD4＋CD25＋调节性 T 细胞（Treg）表达水平，并问卷调查梅毒感染吸毒者的吸毒年限、吸毒类型和吸毒方式。结果吸毒梅毒组 CD4＋CD25＋Treg 水平均高于吸毒非梅毒组和非吸毒梅毒组（P ＜0.01）。在不同期梅毒、不同吸毒类型和不同吸食方式患者中，吸毒年限＞1年者 CD4＋CD25＋Treg 水平均高于≤1年者（P ＜0.01），患者 CD4＋CD25＋Treg水平与吸毒年限呈正相关（R2＝0.672，P ＜0.01）。吸毒患者中，传统与新型毒品均吸食者 CD4＋CD25＋Treg 水平高于单一的吸食传统食品或新型毒品者（P ＜0.01）。注射与非注射吸毒者 CD4＋CD25＋Treg 水平高于采用注射或非注射一种吸毒方式者，差异均有统计学意义（P 均＜0.01）。吸毒年限＞1年者中，吸食传统毒品者和注射吸毒者 CD4＋CD25＋Treg 水平分别高于吸食新型毒品者和非注射吸毒者（P 均＜0.01）。结论吸毒男性梅毒感染者 CD4＋CD25＋Treg 表达增高可能导致的细胞免疫功能抑制与吸毒年限有关，并受毒品类型和吸毒方式影响。
목적：탐토흡독남성매독감염자 CD4＋CD25＋조절성 T 세포표체정황급기영향인소。방법측정144례흡독남성매독감염자、41례흡독남성비매독감염자、35례남성단순매독감염자화35명건강남성적 CD4＋CD25＋조절성 T 세포（Treg）표체수평，병문권조사매독감염흡독자적흡독년한、흡독류형화흡독방식。결과흡독매독조 CD4＋CD25＋Treg 수평균고우흡독비매독조화비흡독매독조（P ＜0.01）。재불동기매독、불동흡독류형화불동흡식방식환자중，흡독년한＞1년자 CD4＋CD25＋Treg 수평균고우≤1년자（P ＜0.01），환자 CD4＋CD25＋Treg수평여흡독년한정정상관（R2＝0.672，P ＜0.01）。흡독환자중，전통여신형독품균흡식자 CD4＋CD25＋Treg 수평고우단일적흡식전통식품혹신형독품자（P ＜0.01）。주사여비주사흡독자 CD4＋CD25＋Treg 수평고우채용주사혹비주사일충흡독방식자，차이균유통계학의의（P 균＜0.01）。흡독년한＞1년자중，흡식전통독품자화주사흡독자 CD4＋CD25＋Treg 수평분별고우흡식신형독품자화비주사흡독자（P 균＜0.01）。결론흡독남성매독감염자 CD4＋CD25＋Treg 표체증고가능도치적세포면역공능억제여흡독년한유관，병수독품류형화흡독방식영향。
Objective To explore the expression level and influencing factors of CD4 +CD25 + regulatory cells(Treg)among male drug -abusers with syphilis.Methods 144 male drug -abusers with syphilis,41 male drug -abusers without syphilis,35 male non -drug abuser with syphilis and 35 male healthy volunteers were enrolled in this study.Expression levels of CD4 +CD25 +Treg of them were detected.A questionnaire interview was conducted among these participants, including drug abuse duration,drug types and abuse ways.Results The levels of Treg expression of drug -abusers with syphilis were significantly higher than that of drug -abusers without syphilis and non -drug abuser with syphilis (P <0.01 ).Despite of the stage of syphilis,types of drugs and abuse way,Treg expression levels with drug abuse duration of"above 1 -year"were significantly higher than those of "1 -year or below"(P <0.01 ).Treg expression levels were positively correlated to drug abuse duration (R2 =0.672,P <0.01)among patients.Among the participants,people both with traditional and new drugs were significantly higher than that with only traditional or new drug (P <0.01).In addition, people both with injecting and non -injecting abuse were significantly higher than that with one way of drug -abuse (P <0.01).Among those with drug abuse duration of "above 1 -year",Treg levels of drug -abusers with traditional drugs and injecting abuse way were remarkably higher than that with new drug and non -injecting abuse respectively (P <0.01). Conclusion Among male drug -abusers with syphilis,suppression of cellular immune function resulting from increased CD4 +CD25 +regulatory T cells is related to drug abuse duration,and is also influenced by drug types and abuse ways.