CAJ | 학술논문

作为珠蛋白家族的第四名成员，胞红蛋白在缺氧条件下的表达明显增强。其在生物体内分布广泛，具有多种重要的生物学功能，如抗氧化应激、抗纤维化、神经保护作用以及在心血管疾病、癌症等和缺氧有关的疾病中起到一定的保护作用。文中综合了近年来的研究成果，就胞红蛋白的结构与分布，抗纤维化、抗癌、促进肌肉再生等相关生理功能以及在缺氧下的表达调节和表达机制作一综述。
작위주단백가족적제사명성원，포홍단백재결양조건하적표체명현증강。기재생물체내분포엄범，구유다충중요적생물학공능，여항양화응격、항섬유화、신경보호작용이급재심혈관질병、암증등화결양유관적질병중기도일정적보호작용。문중종합료근년래적연구성과，취포홍단백적결구여분포，항섬유화、항암、촉진기육재생등상관생리공능이급재결양하적표체조절화표체궤제작일종술。
As the fourth member of the globin family, cytoglobin ( CYGB) is a hypoxia-induced gene, and its expression is upregulated under hypoxia.CYGB is widely distributed in the living body and has a variety of physiological functions, such as anti-oxi-dative stress, anti-fibrosis, and neuroprotection.It also plays a protective role in cardiovascular disease, cancer, and other hypoxia-re-lated diseases.This article presents an overview on the structure and distribution of CYGB, its physiological functions of anti-fibrosis, anti-cancer and muscle regeneration, and the regulation and the mechanism of its expression under hypoxia.