CAJ | 학술논문

类风湿关节炎（ rheumatoid arthristis， RA）是以滑膜增生和外周关节对称性、侵蚀性关节炎为主要特征的慢性炎症性疾病。 Stat3基因是影响成纤维样滑膜细胞的凋亡、代谢的调节因子，并参与RA的发病过程。而SirT1基因是与骨形成相关的调节因子，近年有学者提出其与RA相关。文中综述这2种基因在RA发病机制和靶向治疗方面的研究进展，预测这2种基因在RA发病机制中可能存在的关系。
류풍습관절염（ rheumatoid arthristis， RA）시이활막증생화외주관절대칭성、침식성관절염위주요특정적만성염증성질병。 Stat3기인시영향성섬유양활막세포적조망、대사적조절인자，병삼여RA적발병과정。이SirT1기인시여골형성상관적조절인자，근년유학자제출기여RA상관。문중종술저2충기인재RA발병궤제화파향치료방면적연구진전，예측저2충기인재RA발병궤제중가능존재적관계。
Rheumatoid arthritis ( RA) is a chronic inflammatory disease involving progressive articular damage cause by inflam-matory cells and synoviocytes.Stat3 gene, which is confirmed to play a role in the pathogenesis of RA, regulates the metabolism and apoptosis of the fibroblast-like synoviocytes ( FLS) .SirT1 gene relating to the bone formation was indicated to play a role in the patho-genesis of RA in recent years.This review introduces the pathogenesis and targeted treatment of RA and makes a prediction about the relation between Stat3 and SirT1 gene.We hope it will provide a new direction for the research of RA.