天津医药
天津醫藥
천진의약
TIANJIN MEDICAL JOURNAL
2015年
9期
1012-1014
,共3页
多囊卵巢综合征%神经生长因子%血清%卵泡液
多囊卵巢綜閤徵%神經生長因子%血清%卵泡液
다낭란소종합정%신경생장인자%혈청%란포액
polycystic ovary syndrome%nerve growth factor%serum%follicular fluid
目的：检测多囊卵巢综合征（PCOS）患者血清与卵泡液中神经生长因子（NGF）水平，探讨NGF水平与PCOS发生的相关性以及对PCOS患者助孕结局的影响。方法收集2011年12月—2012年11月在唐山市妇幼保健院生殖遗传科行体外受精-胚胎移植（IVF-ET）的PCOS患者65例及同期因输卵管因素行IVF-ET的非PCOS患者31例作为对照组。采用ELISA检测96例患者绒毛膜促性腺激素（HCG）注射日血清和取卵日卵泡液中NGF的水平。比较PCOS组与正常对照组妊娠与未妊娠患者血清与卵泡液中NGF的水平。结果 PCOS患者血清[（14.38±0.42）ng/L]及卵泡液[（9.61±0.49）ng/L]中的NGF水平明显高于正常对照组[（11.39±0.38）ng/L、(7.55±0.40）ng/L]；PCOS患者妊娠组血清[（14.22±0.35）ng/L]和卵泡液[（9.30±0.31）ng/L]中的NGF水平低于未妊娠组[（14.51±0.43）ng/L、（9.86±0.46）ng/L]，差异有统计学意义（均P＜0.01）。结论 PCOS患者血清和卵泡液内存在NGF水平高表达，血清和卵泡液内过高的NGF水平可能不利于PCOS患者成功妊娠。
目的：檢測多囊卵巢綜閤徵（PCOS）患者血清與卵泡液中神經生長因子（NGF）水平，探討NGF水平與PCOS髮生的相關性以及對PCOS患者助孕結跼的影響。方法收集2011年12月—2012年11月在唐山市婦幼保健院生殖遺傳科行體外受精-胚胎移植（IVF-ET）的PCOS患者65例及同期因輸卵管因素行IVF-ET的非PCOS患者31例作為對照組。採用ELISA檢測96例患者絨毛膜促性腺激素（HCG）註射日血清和取卵日卵泡液中NGF的水平。比較PCOS組與正常對照組妊娠與未妊娠患者血清與卵泡液中NGF的水平。結果 PCOS患者血清[（14.38±0.42）ng/L]及卵泡液[（9.61±0.49）ng/L]中的NGF水平明顯高于正常對照組[（11.39±0.38）ng/L、(7.55±0.40）ng/L]；PCOS患者妊娠組血清[（14.22±0.35）ng/L]和卵泡液[（9.30±0.31）ng/L]中的NGF水平低于未妊娠組[（14.51±0.43）ng/L、（9.86±0.46）ng/L]，差異有統計學意義（均P＜0.01）。結論 PCOS患者血清和卵泡液內存在NGF水平高錶達，血清和卵泡液內過高的NGF水平可能不利于PCOS患者成功妊娠。
목적：검측다낭란소종합정（PCOS）환자혈청여란포액중신경생장인자（NGF）수평，탐토NGF수평여PCOS발생적상관성이급대PCOS환자조잉결국적영향。방법수집2011년12월—2012년11월재당산시부유보건원생식유전과행체외수정-배태이식（IVF-ET）적PCOS환자65례급동기인수란관인소행IVF-ET적비PCOS환자31례작위대조조。채용ELISA검측96례환자융모막촉성선격소（HCG）주사일혈청화취란일란포액중NGF적수평。비교PCOS조여정상대조조임신여미임신환자혈청여란포액중NGF적수평。결과 PCOS환자혈청[（14.38±0.42）ng/L]급란포액[（9.61±0.49）ng/L]중적NGF수평명현고우정상대조조[（11.39±0.38）ng/L、(7.55±0.40）ng/L]；PCOS환자임신조혈청[（14.22±0.35）ng/L]화란포액[（9.30±0.31）ng/L]중적NGF수평저우미임신조[（14.51±0.43）ng/L、（9.86±0.46）ng/L]，차이유통계학의의（균P＜0.01）。결론 PCOS환자혈청화란포액내존재NGF수평고표체，혈청화란포액내과고적NGF수평가능불리우PCOS환자성공임신。
Objective To investigate the relationship of nerve growth factor (NGF) between serum and follicular fluid in patients with polycystic ovary syndrome (PCOS), and its effect on pregnancy outcomes. Methods From December 2011 to November 2012, 65 PCOS patients suffered with in vitro fertilization-embryo transfer (IVF-ET) were included in PCOS group and 31 non-PCOS patients with IVF-ET were used as control group. The expressions of NGF in serum and follicular fluid were detected by ELISA on the injection day of chorionic gonadotropin (HCG). The expression levels of NGF in serum and follicular fluid were compared between PCOS group and control group. Results The NGF levels in serum[(14.38±0.42) ng/L] and follicular fluid[(9.61±0.49)ng/L] were significantly higher in PCOS group than those of control group[(11.39±0.38) ng/L and (7.55 ± 0.40)ng/L]. In PCOS group, NGF levels in serum [(14.22 ± 0.35)ng/L] and follicular fluid [(9.30 ± 0.31)ng/L] were significantly lower in pregnant group than those of non-pregnant group[(14.51±0.43)ng/L, (9.86±0.46)ng/L, P<0.01]. Conclusion The increased levels of NGF in serum and follicular fluid of PCOS patients contribute to the pathogenesis of PCOS. The high expression of NGF in serum and follicular fluid may be harmful to pregnancy in PCOS patients.
