CAJ | 학술논문

背景：胎盘间充质干细胞因其具有来源广泛、免疫原性低、不涉及伦理问题等优点成为种子细胞的新来源。 　　目的：阐述胎盘间充质干细胞的来源、生物学特性及应用最新研究进展。 　　方法：检索 PubMed、ScienceDirect、OvidSP、CNKI数据库相关文章，检索时限为2003至2015年，英文检索词为“Placenta，Mesenchymal stem cels，The placenta mesenchymal stem cels, Cel transplantation , Application mechanism”，中文检索词为“胎盘，间充质干细胞，胎盘间充质干细胞，细胞移植，应用机制”，从中筛选出与主题相关且论据可靠的部分文献，最终纳入57篇文章进行归纳综述。 　　结果与结论：目前已成功分离培养出胎盘间充质干细胞，并对其生物学特性进行研究，证明其具有干细胞源性及多向分化潜能。目前有较多关于胎盘间充质干细胞应用于实验动物及临床的研究，在骨组织工程、血管再生及神经组织等修复过程中均显示出了巨大的潜力，但胎盘间充质干细胞的具体应用机制目前尚不清楚，尚处于探索阶段，在胎盘间充质干细胞广泛应用于临床之前，仍有许多问题有待进一步研究明确，以确保其安全性和有效性。
배경：태반간충질간세포인기구유래원엄범、면역원성저、불섭급윤리문제등우점성위충자세포적신래원。 　　목적：천술태반간충질간세포적래원、생물학특성급응용최신연구진전。 　　방법：검색 PubMed、ScienceDirect、OvidSP、CNKI수거고상관문장，검색시한위2003지2015년，영문검색사위“Placenta，Mesenchymal stem cels，The placenta mesenchymal stem cels, Cel transplantation , Application mechanism”，중문검색사위“태반，간충질간세포，태반간충질간세포，세포이식，응용궤제”，종중사선출여주제상관차론거가고적부분문헌，최종납입57편문장진행귀납종술。 　　결과여결론：목전이성공분리배양출태반간충질간세포，병대기생물학특성진행연구，증명기구유간세포원성급다향분화잠능。목전유교다관우태반간충질간세포응용우실험동물급림상적연구，재골조직공정、혈관재생급신경조직등수복과정중균현시출료거대적잠력，단태반간충질간세포적구체응용궤제목전상불청초，상처우탐색계단，재태반간충질간세포엄범응용우림상지전，잉유허다문제유대진일보연구명학，이학보기안전성화유효성。
BACKGROUND:Placental mesenchymal stem cels are becoming a new source of seed cels because of wide range of sources, low immunogenicity and not involving ethical issues. OBJECTIVE:To elaborate the sources, biological characteristics and latest application of placental mesenchymal stem cels. METHODS:Literature search was performed in PubMed, ScienceDirect, OvidSP, CNKI databases for relevant literatures published from 2003 to 2015. The key words were “placenta, mesenchymal stem cels, placenta mesenchymal stem cels, cel transplantation, application mechanism” in Chinese and English, respectively. Then, 57 papers were further analyzed and reviewed in line with the theme. RESULTS AND CONCLUSION:Placental mesenchymal stem cels have been isolated and cultured successfuly, and confirmed to have multi-differentiation potential. A large number of placental mesenchymal stem cels have been used in the experimental animal and clinical researches, and they have a great potential in bone tissue engineering, revascularizaion and nerve repair. However, the specific mechanism underlying the application of placental mesenchymal stem cels is not clear. In order to ensure the safety and effectiveness, there are stil many problems to be further studied before placental mesenchymal stem cels are widely used in clinic.