CAJ | 학술논문

目的：分析DC联合CIK细胞治疗对中晚期肝癌患者免疫功能及生活质量的影响。方法回顾性分析50例中晚期肝癌患者的临床资料，并采用流式细胞仪检测患者治疗前后免疫功能变化和生活质量情况。结果50例患者治疗后，T辅助细胞、总T细胞、细胞毒T细胞、Th/Ts比值、调节T细胞、自然杀伤细胞以及NK-T细胞均比治疗前显著提高，治疗前后比较差异有统计学意义（P<0.05）；治疗前卡氏评分平均为（75.4±10.2）分，而治疗后平均评分为（84.5±11.34）分，2组比较差异有统计学意义（P<0.05），无严重不良反应。结论 DC联合CIK细胞治疗中晚期肝癌患者，不仅能够有效提高患者免疫功能，改善患者生活质量，而且治疗安全性及可行性高，值得临床推广使用。
목적：분석DC연합CIK세포치료대중만기간암환자면역공능급생활질량적영향。방법회고성분석50례중만기간암환자적림상자료，병채용류식세포의검측환자치료전후면역공능변화화생활질량정황。결과50례환자치료후，T보조세포、총T세포、세포독T세포、Th/Ts비치、조절T세포、자연살상세포이급NK-T세포균비치료전현저제고，치료전후비교차이유통계학의의（P<0.05）；치료전잡씨평분평균위（75.4±10.2）분，이치료후평균평분위（84.5±11.34）분，2조비교차이유통계학의의（P<0.05），무엄중불량반응。결론 DC연합CIK세포치료중만기간암환자，불부능구유효제고환자면역공능，개선환자생활질량，이차치료안전성급가행성고，치득림상추엄사용。
Objective Analysis of DC combined with CIK cells for the effects on immune function in patients with liver cancer in advanced stage and quality of life.Methods Retrospective analysis Clinical data of 50 patients with advanced hepatocellular carcinoma and the use of lfow cytometry to detect the changes of immune function and quality of life before and after treatment.Results This group of 50 patients after treatment, T helper cells, total T cells, cytotoxic T cell, Th/Ts ratio, regulatory T cells, natural killer cells and NK-T cells were all improved than before treatment, after treatment, the difference has statistical signiifcance; Karnofsky performance status for an average of (75.4±10.2) points, and after treatment themean score of (84.5±11.34), between the two groups difference is statistically signiifcant (P<0.05), no serious adverse reaction.Conclusion In patients with advanced hepatocellular carcinoma DC cells combined with CIK treatment, not only can improve the immune function of patients, improve the quality of life of patients, but also the treatment of safety and high feasibility, is worthy of clinical use.