CAJ | 학술논문

目的：分析早期补充维生素D对早产儿白细胞介素-2(IL-2)和各免疫球蛋白浓度的影响。方法选取我院2013年9月至2014年9月收治的早产儿200例，其中小龄儿、大龄儿各100例，随后按随机数表法将大小胎龄儿分别分为观察组与对照组，每组50例。小龄儿分别记为观察组1和对照组1，大龄儿分别记为观察组2和对照组2。对照组幼儿出生3d后给予配方奶喂养，观察组幼儿则在对照组幼儿的基础上口服维生素D。在胎儿出生后3 d和10 d测定幼儿血清IL-2及免疫球蛋白-G (IgG)、免疫球蛋白-A (IgA)、免疫球蛋白-M (IgM)、25羟维生素D[25-(OH)D]等水平，借此分析对比幼儿身体健康状况。结果观察组1中3 d和10 d时幼儿血清25-(OH) D浓度平均值分别为(22.921±6.253) nmol/L、(27.51±6.932) nmol/L，观察组2中分别为(28.121±8.253) nmol/L、(33.192±8.932) nmol/L，两组数据比较差异均具有统计学意义(P<0.05)，且两观察组幼儿25-(OH)D浓度均明显高于对照组，差异均有统计学意义(P<0.05)。观察组1中3 d和10 d时幼儿IL-2浓度平均值分别为(3.121±2.19) pg/L、(4.623±2.80) pg/L，观察组2中3 d和10 d时幼儿血清IL-2浓度平均值分别为(3.29±1.12) pg/L、(3.35±2.32) pg/L，两组比较差异具有统计学意义(P<0.05)。第10天观察组1、2的IL-2浓度均明显高于第3天时的IL-2浓度，差异有统计学意义(P<0.05)。观察组1幼儿的IL-2浓度明显高于对照组1幼儿，差异具有统计学意义(P<0.05)。而早产儿出生第3天、第10天时的血清IgA、IgG、IgM浓度均无统计学意义(P>0.05)。结论早产儿早期适当补充维生素D有助于提高IL-2以及25-(OH) D浓度，增强免疫力，但维生素D对于IgA、IgG、IgM浓度影响尚未得以证实。
목적：분석조기보충유생소D대조산인백세포개소-2(IL-2)화각면역구단백농도적영향。방법선취아원2013년9월지2014년9월수치적조산인200례，기중소령인、대령인각100례，수후안수궤수표법장대소태령인분별분위관찰조여대조조，매조50례。소령인분별기위관찰조1화대조조1，대령인분별기위관찰조2화대조조2。대조조유인출생3d후급여배방내위양，관찰조유인칙재대조조유인적기출상구복유생소D。재태인출생후3 d화10 d측정유인혈청IL-2급면역구단백-G (IgG)、면역구단백-A (IgA)、면역구단백-M (IgM)、25간유생소D[25-(OH)D]등수평，차차분석대비유인신체건강상황。결과관찰조1중3 d화10 d시유인혈청25-(OH) D농도평균치분별위(22.921±6.253) nmol/L、(27.51±6.932) nmol/L，관찰조2중분별위(28.121±8.253) nmol/L、(33.192±8.932) nmol/L，량조수거비교차이균구유통계학의의(P<0.05)，차량관찰조유인25-(OH)D농도균명현고우대조조，차이균유통계학의의(P<0.05)。관찰조1중3 d화10 d시유인IL-2농도평균치분별위(3.121±2.19) pg/L、(4.623±2.80) pg/L，관찰조2중3 d화10 d시유인혈청IL-2농도평균치분별위(3.29±1.12) pg/L、(3.35±2.32) pg/L，량조비교차이구유통계학의의(P<0.05)。제10천관찰조1、2적IL-2농도균명현고우제3천시적IL-2농도，차이유통계학의의(P<0.05)。관찰조1유인적IL-2농도명현고우대조조1유인，차이구유통계학의의(P<0.05)。이조산인출생제3천、제10천시적혈청IgA、IgG、IgM농도균무통계학의의(P>0.05)。결론조산인조기괄당보충유생소D유조우제고IL-2이급25-(OH) D농도，증강면역력，단유생소D대우IgA、IgG、IgM농도영향상미득이증실。
Objective To analyze the early effect of vitamin D on interleukin IL-2 (IL-2) levels and the im-mune globulin protein concentrations in premature infants. Methods Two hundred premature infants were selected in our hospital from September 2013 to September 2014, including 100 infants of small age and 100 infants of older age. The small age infants and the older age infants were then divided into observation group and control group accord-ing to the random number table, respectively:observation group 1 and control group 1 of small age infants, observa-tion group 2 and control group 2 of older age infants, with 50 cases in each group. The infants in control group 1 and control group 2 were given formula feeding three days later born, while the infants of observation group 1 and observa-tion group 2 were given oral vitamin D based on formula feeding. At postnatal 3 d and 10 d, the serum IL-2 and immu-noglobulin G (IgG) and immune globulin A (IgA), immunoglobulin M (IgM), 25 hydroxyvitamin D [25-(OH)D] lev-els were determined, and infants’health status were analyzed. Results The average values of serum 25(OH)D con-centration at postnatal 3 d and 10 d were (22.921 ± 6.253) nmol/L, (27.51 ± 6.932) nmol/L in observation group 1 and (28.121±8.253) nmol/L, (33.192±8.932) nmol/L in observation group 1, with statistical significant differences between the two observation groups (P<0.05). And the 25-(OH)D concentrations in the two observation groups were signifi-cantly higher than those in the two control groups (P<0.05). The average values of IL-2 level at postnatal 3 d and 10 d were (3.121±2.19) pg/L, (4.623±2.80) pg/L in observation group 1 and (3.29±1.12) pg/L, (3.35±2.32) pg/L in observa-tion group 2, with statistically significant differences between the two groups (P<0.05). The IL-2 levels at postnatal 10 d were significantly higher than those at postnatal 3 d in the two observation groups (P<0.05). The IL-2 levels in observation group 1 were significantly higher than those in control group 1 (P<0.05). The serum IgA, IgG, IgM con-centrations at postnatal 3 d and 10 d showed no significant changes (P>0.05). Conclusion Early preterm infants tak-ing appropriate vitamin D helps improve the IL-2 and 25(OH)D concentrations and enhance immunity, but the effects of vitamin D on IgA, IgG, IgM concentrations are yet to be confirmed.