口腔医学
口腔醫學
구강의학
STOMATOLOGY
2015年
9期
739-743
,共5页
细胞因子/趋化因子%慢性牙周病%Ⅱ型糖尿病
細胞因子/趨化因子%慢性牙週病%Ⅱ型糖尿病
세포인자/추화인자%만성아주병%Ⅱ형당뇨병
cytokines/chemokines%chronic periodontitis%type Ⅱ diabetes mellitus
目的:探讨Ⅱ型糖尿病合并牙周病患者与单纯牙周病患者龈沟液(gingival crevicular fluid,GCF)中细胞因子/趋化因子的表达水平。方法选取伴Ⅱ型糖尿病的牙周病患者52例,单纯牙周病患者40例,用Luminex FLEXMAP3D 仪和Human Cytokine / Chemokine 试剂盒检测GCF 中14种细胞因子/趋化因子的表达水平。结果牙周病部位:嗜酸性粒细胞趋化因子、巨噬细胞炎症蛋白-1α、粒细胞-巨噬细胞集落刺激、白介素-6、肿瘤坏死因子-α和白介素-12的浓度,糖尿病组受试者高于非糖尿病组受试者( P <0.0035)。结论糖尿病可影响牙周病部位细胞因子/趋化因子的表达,糖尿病可能是牙周病的促进因素。
目的:探討Ⅱ型糖尿病閤併牙週病患者與單純牙週病患者齦溝液(gingival crevicular fluid,GCF)中細胞因子/趨化因子的錶達水平。方法選取伴Ⅱ型糖尿病的牙週病患者52例,單純牙週病患者40例,用Luminex FLEXMAP3D 儀和Human Cytokine / Chemokine 試劑盒檢測GCF 中14種細胞因子/趨化因子的錶達水平。結果牙週病部位:嗜痠性粒細胞趨化因子、巨噬細胞炎癥蛋白-1α、粒細胞-巨噬細胞集落刺激、白介素-6、腫瘤壞死因子-α和白介素-12的濃度,糖尿病組受試者高于非糖尿病組受試者( P <0.0035)。結論糖尿病可影響牙週病部位細胞因子/趨化因子的錶達,糖尿病可能是牙週病的促進因素。
목적:탐토Ⅱ형당뇨병합병아주병환자여단순아주병환자간구액(gingival crevicular fluid,GCF)중세포인자/추화인자적표체수평。방법선취반Ⅱ형당뇨병적아주병환자52례,단순아주병환자40례,용Luminex FLEXMAP3D 의화Human Cytokine / Chemokine 시제합검측GCF 중14충세포인자/추화인자적표체수평。결과아주병부위:기산성립세포추화인자、거서세포염증단백-1α、립세포-거서세포집락자격、백개소-6、종류배사인자-α화백개소-12적농도,당뇨병조수시자고우비당뇨병조수시자( P <0.0035)。결론당뇨병가영향아주병부위세포인자/추화인자적표체,당뇨병가능시아주병적촉진인소。
Objective To explore the expression levels of cyto / chemokines in the gingival crevicular fluid (GCF)of type Ⅱ diabet-ic mellitus subjects with chronic periodontitis compared with those with simple periodontitis. Methods Fifty-two type Ⅱ diabetic mel-litus subjects and forty non-diabetic mellitus subjects with chronic periodontitis were enrolled in this study. The levels of 14 cyto / chemo-kines were measured in the GCF of healthy and diseased sites of the diabetic and non-diabetic mellitus subjects with chronic periodonti-tis using Luminex FLEXMAP3D plate reader and Human Cytokine / Chemokine kits. Results The concentrations of eotaxin,macro-phage inflammatory protein-1α,granulocyte-macrophage colony-stimulating factor,interleukin (IL)-6,tumour necrosis factor-α and IL-12 were higher at healthy and diseased sites of diabetic mellitus than non-diabetic mellitus subjects. Conclusions Type Ⅱ diabetes mellitus modulated the levels of several cyto / chemokines at both healthy and diseased periodontal sites. It may be a facilitating factor to periodontal disease.