中国神经精神疾病杂志
中國神經精神疾病雜誌
중국신경정신질병잡지
CHINESE JOURNAL OF NERVOUS AND MENTAL DISEASES
2015年
8期
477-481
,共5页
贾凤南%汤浩%史家波%刘楚%卢青%姚志剑
賈鳳南%湯浩%史傢波%劉楚%盧青%姚誌劍
가봉남%탕호%사가파%류초%로청%요지검
双相障碍%脑磁图%静息态
雙相障礙%腦磁圖%靜息態
쌍상장애%뇌자도%정식태
Bipolar disorder%Magnetoencephalography%Resting state
目的：探究中青年双相障碍抑郁发作患者静息脑磁频谱分布特征、额叶α波偏侧化及其与临床症状的相关性。方法对12例20~45岁中青年双相抑郁患者（患者组）和24名年龄、受教育年限相匹配的正常对照者（对照组）进行静息态脑磁图扫描。采用置换检验比较两组δ、θ、α1、α2、α3、β频段在双侧中央、额叶、颞叶、顶叶、枕叶等感兴趣皮质区相对能量值和偏侧化指数，并分析患者组中与对照组有差异的脑区能量值与汉密尔顿抑郁量表17项（Hamilton depression rating scale，HAMD17）总分及各因子分的相关关系。结果与对照组相比，患者组δ、θ和β频段能量增加：δ频段能量异常分布于左中央区、左枕区（P<0.05，未校正），θ频段能量异常分布于左枕区（P<0.05，未校正），β频段分布于左中央区、右额叶及双侧顶叶。与对照组相比，患者组双侧颞叶在α2及α3频段能量减弱（P<0.05，未校正）。右颞区α3频段能量值与HAMD17认知因子分呈负相关（r=-0.648，P=0.026）。结论双相抑郁患者存在多个频段皮层激活异常，其认知障碍症状可能与α3异常活动有关。
目的：探究中青年雙相障礙抑鬱髮作患者靜息腦磁頻譜分佈特徵、額葉α波偏側化及其與臨床癥狀的相關性。方法對12例20~45歲中青年雙相抑鬱患者（患者組）和24名年齡、受教育年限相匹配的正常對照者（對照組）進行靜息態腦磁圖掃描。採用置換檢驗比較兩組δ、θ、α1、α2、α3、β頻段在雙側中央、額葉、顳葉、頂葉、枕葉等感興趣皮質區相對能量值和偏側化指數，併分析患者組中與對照組有差異的腦區能量值與漢密爾頓抑鬱量錶17項（Hamilton depression rating scale，HAMD17）總分及各因子分的相關關繫。結果與對照組相比，患者組δ、θ和β頻段能量增加：δ頻段能量異常分佈于左中央區、左枕區（P<0.05，未校正），θ頻段能量異常分佈于左枕區（P<0.05，未校正），β頻段分佈于左中央區、右額葉及雙側頂葉。與對照組相比，患者組雙側顳葉在α2及α3頻段能量減弱（P<0.05，未校正）。右顳區α3頻段能量值與HAMD17認知因子分呈負相關（r=-0.648，P=0.026）。結論雙相抑鬱患者存在多箇頻段皮層激活異常，其認知障礙癥狀可能與α3異常活動有關。
목적：탐구중청년쌍상장애억욱발작환자정식뇌자빈보분포특정、액협α파편측화급기여림상증상적상관성。방법대12례20~45세중청년쌍상억욱환자（환자조）화24명년령、수교육년한상필배적정상대조자（대조조）진행정식태뇌자도소묘。채용치환검험비교량조δ、θ、α1、α2、α3、β빈단재쌍측중앙、액협、섭협、정협、침협등감흥취피질구상대능량치화편측화지수，병분석환자조중여대조조유차이적뇌구능량치여한밀이돈억욱량표17항（Hamilton depression rating scale，HAMD17）총분급각인자분적상관관계。결과여대조조상비，환자조δ、θ화β빈단능량증가：δ빈단능량이상분포우좌중앙구、좌침구（P<0.05，미교정），θ빈단능량이상분포우좌침구（P<0.05，미교정），β빈단분포우좌중앙구、우액협급쌍측정협。여대조조상비，환자조쌍측섭협재α2급α3빈단능량감약（P<0.05，미교정）。우섭구α3빈단능량치여HAMD17인지인자분정부상관（r=-0.648，P=0.026）。결론쌍상억욱환자존재다개빈단피층격활이상，기인지장애증상가능여α3이상활동유관。
Objective To explore the resting state cortical activity and frontal asymmetry in alpha oscillations in bipolar depressive patients and its relationship with clinical symptoms. Methods Twelve bipolar depressive patients (pa?tient group) and twenty-four well-matched healthy volunteer (control group) were underwent whole head MEG recording. Individual spectral power and frontal asymmetry index were calculated by using permutation test to discover the differenc?es in δ, θ, α1, α2, α3, β bands between the two groups among the regions of interested (bilateral central, frontal lobe, temporal lobe, parietal lobe, occipital lobe). The correlation analysis were used to analyze the association between power of brain regions with significant difference and the Hamilton depression rating scale17 scores as well as factor items in patients. Results Compared with the control group, the activity of various regions was increased in the patient group as follows:theδband in the left central and left occipital lobes, theθband in the left occipital lobe, theβband in left cen?tral, right frontal, left parietal lobe and right parietal lobe. The power ofα2 andα3 frequency bands was decreased in the bilateral temporal lobes (P<0.05, uncorrected). A negative correlation was observed between the right temporalα3 power and recognition item scores for bipolar depression (P<0.05). Conclusion The present study suggests that bipolar depres?sive patients have impaired neural activity at many bands and the symptom of cognitive impairment may be associated with dysfunction ofα3 band.
