中国生化药物杂志
中國生化藥物雜誌
중국생화약물잡지
CHINESE JOURNAL OF BIOCHEMICAL PHARMACEUTICS
2015年
8期
164-166
,共3页
双氯芬酸钠盐酸利多卡因%山莨菪碱%骨折%镇痛%安全性
雙氯芬痠鈉鹽痠利多卡因%山莨菪堿%骨摺%鎮痛%安全性
쌍록분산납염산리다잡인%산랑탕감%골절%진통%안전성
diclofenac sodium and lidocaine hydrochloride%anisodamine%bone fracture%analgesia%safety
目的：探讨双氯芬酸钠盐酸利多卡因联合山莨菪碱对骨折疼痛患者镇痛疗效及安全性。方法收集海南省海口市人民医院收治的急性骨折患者54例，随机分为对照组和实验组，每组各27例，对照组给予双氯芬酸钠盐酸利多卡因镇痛，实验组在对照组基础上给予山莨菪碱镇痛，治疗前30 min和治疗2 h后，对所有患者的血浆5－羟色胺（5－hydroxytryptamine，5－HT）、前列腺素E2（prostaglandin E2，PGE2）含量、镇痛效果、耐受性及不良反应情况进行检测。结果治疗后，与对照组比较，实验组患者的血浆5－HT含量均明显较低（P＜0．05），实验组患者的血浆PGE2含量较低（P＜0．05）；实验组患者疼痛分级指数（pain rating index，PRI）的总分、感觉分、情绪分及现有疼痛强度（present pain intensity，PPI）、疼痛视觉模拟评分（visual analogue scale，VAS）均明显较低（P＜0．05）。实验组患者的不良反应耐受性（92．59％）明显高于对照组（66．67％）（χ2＝5．59，P＜0．05）。结论双氯芬酸钠盐酸利多卡因联合山莨菪碱能够明显降低骨折疼痛患者血浆5－HT和PGE2，提高镇痛效果，减少不良反应的发生，患者耐受性较好。
目的：探討雙氯芬痠鈉鹽痠利多卡因聯閤山莨菪堿對骨摺疼痛患者鎮痛療效及安全性。方法收集海南省海口市人民醫院收治的急性骨摺患者54例，隨機分為對照組和實驗組，每組各27例，對照組給予雙氯芬痠鈉鹽痠利多卡因鎮痛，實驗組在對照組基礎上給予山莨菪堿鎮痛，治療前30 min和治療2 h後，對所有患者的血漿5－羥色胺（5－hydroxytryptamine，5－HT）、前列腺素E2（prostaglandin E2，PGE2）含量、鎮痛效果、耐受性及不良反應情況進行檢測。結果治療後，與對照組比較，實驗組患者的血漿5－HT含量均明顯較低（P＜0．05），實驗組患者的血漿PGE2含量較低（P＜0．05）；實驗組患者疼痛分級指數（pain rating index，PRI）的總分、感覺分、情緒分及現有疼痛彊度（present pain intensity，PPI）、疼痛視覺模擬評分（visual analogue scale，VAS）均明顯較低（P＜0．05）。實驗組患者的不良反應耐受性（92．59％）明顯高于對照組（66．67％）（χ2＝5．59，P＜0．05）。結論雙氯芬痠鈉鹽痠利多卡因聯閤山莨菪堿能夠明顯降低骨摺疼痛患者血漿5－HT和PGE2，提高鎮痛效果，減少不良反應的髮生，患者耐受性較好。
목적：탐토쌍록분산납염산리다잡인연합산랑탕감대골절동통환자진통료효급안전성。방법수집해남성해구시인민의원수치적급성골절환자54례，수궤분위대조조화실험조，매조각27례，대조조급여쌍록분산납염산리다잡인진통，실험조재대조조기출상급여산랑탕감진통，치료전30 min화치료2 h후，대소유환자적혈장5－간색알（5－hydroxytryptamine，5－HT）、전렬선소E2（prostaglandin E2，PGE2）함량、진통효과、내수성급불량반응정황진행검측。결과치료후，여대조조비교，실험조환자적혈장5－HT함량균명현교저（P＜0．05），실험조환자적혈장PGE2함량교저（P＜0．05）；실험조환자동통분급지수（pain rating index，PRI）적총분、감각분、정서분급현유동통강도（present pain intensity，PPI）、동통시각모의평분（visual analogue scale，VAS）균명현교저（P＜0．05）。실험조환자적불량반응내수성（92．59％）명현고우대조조（66．67％）（χ2＝5．59，P＜0．05）。결론쌍록분산납염산리다잡인연합산랑탕감능구명현강저골절동통환자혈장5－HT화PGE2，제고진통효과，감소불량반응적발생，환자내수성교호。
Objective To analyse the pain analgesic efficacy and safety evaluation of diclofenac sodium and lidocaine hydrochloride combined with anisodamine in patients with bone fractures.Methods 54 patients who were diagnosed with acute fracture in the hospital were collected and randomly divided into experimental group and control group, 27 cases in each group, control group was treated with diclofenac sodium and lidocaine hydrochloride, and experimental group was treated with anisodamine on the basis of control group.Before 30 min and 2 h after treatment, the effect of 5-hydroxytryptamine ( 5-HT ), prostaglandin E2 ( PGE2 ), analgesic effect, tolerability and adverse reactions were detected in all patients. ResuIts Compared with control group post treatment, the plasma 5-HT content was significantly lower in experimental group ( P<0.05 ); the plasma PGE2 content in experimental group was significantly lower (P<0.05); the pain rating index (PRI) total score,PRI feel score, PRI emotion score, present pain intensity (PPI) and visual analogue scale (VAS) in experimental group was significantly lower (P<0.05).The tolerance of experimental group was 92.59%, which was significantly higher than 66.67% of control group (χ2 =5.59,P<0.05).ConcIusion Diclofenac sodium and lidocaine hydrochloride combined with anisodamine could significantly decrease 5-HT and PGE2 in patients with fracture pain, enhance the analgesic effect, reduce the incidence of adverse reactions, with a good tolerance, which have the guiding significance on clinical therapy.
