中国生化药物杂志
中國生化藥物雜誌
중국생화약물잡지
CHINESE JOURNAL OF BIOCHEMICAL PHARMACEUTICS
2015年
8期
161-163
,共3页
热毒宁注射液%血液净化%多器官功能衰竭%肾功能%免疫功能%老年
熱毒寧註射液%血液淨化%多器官功能衰竭%腎功能%免疫功能%老年
열독저주사액%혈액정화%다기관공능쇠갈%신공능%면역공능%노년
Reduning injection%blood purification%multiple organ failure%renal function%immune function%elder
目的：探讨热毒宁注射液联合血液净化对老年多器官功能衰竭患者肾功能、免疫功能和生命体征的影响。方法选取大连医科大学附属第一医院诊治的老年多器官功能衰竭患者76例，根据随机数字表法随机分为2组：对照组38例，积极采取临床常规血液透析治疗；实验组38例，在对照组基础上联合应用热毒宁注射液治疗，检测2组患者肾功能、免疫功能和生命体征变化。结果治疗后，与对照组比较，实验组血清肌酐（ serum creatinine，Scr）、尿素氮（ blood urea nitrogen，BUN）、尿酸（uric acid，UA）水平较低（P＜0．05）；实验组T淋巴细胞亚群CD3＋、CD4＋、CD4＋／CD8＋水平较高，CD8＋T细胞水平较低（P＜0．05）；实验组血压及24 h尿量较高，呼吸频率及心率较低（ P＜0．05）。结论热毒宁注射液联合血液净化对老年多器官功能衰竭患者治疗据有较好的临床疗效，且能有效改善患者肾脏功能，调节免疫功能，改善生命体征，对临床治疗老年多器官功能衰竭具有重要意义。
目的：探討熱毒寧註射液聯閤血液淨化對老年多器官功能衰竭患者腎功能、免疫功能和生命體徵的影響。方法選取大連醫科大學附屬第一醫院診治的老年多器官功能衰竭患者76例，根據隨機數字錶法隨機分為2組：對照組38例，積極採取臨床常規血液透析治療；實驗組38例，在對照組基礎上聯閤應用熱毒寧註射液治療，檢測2組患者腎功能、免疫功能和生命體徵變化。結果治療後，與對照組比較，實驗組血清肌酐（ serum creatinine，Scr）、尿素氮（ blood urea nitrogen，BUN）、尿痠（uric acid，UA）水平較低（P＜0．05）；實驗組T淋巴細胞亞群CD3＋、CD4＋、CD4＋／CD8＋水平較高，CD8＋T細胞水平較低（P＜0．05）；實驗組血壓及24 h尿量較高，呼吸頻率及心率較低（ P＜0．05）。結論熱毒寧註射液聯閤血液淨化對老年多器官功能衰竭患者治療據有較好的臨床療效，且能有效改善患者腎髒功能，調節免疫功能，改善生命體徵，對臨床治療老年多器官功能衰竭具有重要意義。
목적：탐토열독저주사액연합혈액정화대노년다기관공능쇠갈환자신공능、면역공능화생명체정적영향。방법선취대련의과대학부속제일의원진치적노년다기관공능쇠갈환자76례，근거수궤수자표법수궤분위2조：대조조38례，적겁채취림상상규혈액투석치료；실험조38례，재대조조기출상연합응용열독저주사액치료，검측2조환자신공능、면역공능화생명체정변화。결과치료후，여대조조비교，실험조혈청기항（ serum creatinine，Scr）、뇨소담（ blood urea nitrogen，BUN）、뇨산（uric acid，UA）수평교저（P＜0．05）；실험조T림파세포아군CD3＋、CD4＋、CD4＋／CD8＋수평교고，CD8＋T세포수평교저（P＜0．05）；실험조혈압급24 h뇨량교고，호흡빈솔급심솔교저（ P＜0．05）。결론열독저주사액연합혈액정화대노년다기관공능쇠갈환자치료거유교호적림상료효，차능유효개선환자신장공능，조절면역공능，개선생명체정，대림상치료노년다기관공능쇠갈구유중요의의。
Objective To investigate the effect of Reduning injection combined with blood purification on vital signs, renal fuction and immune function in elderly patients with multiple organ failure .Methods 76 patients with multiple organ failure were selected in the hospital and randomly divided into two groups.38 patients in control group were treated with actively conventional hematodialysis treatment, and 38 patients in experiment group were treated on the basis of control group with Reduning injection.The changes of vital signs, renal fuction and immune function were compared before and after treatment, and then the efficacy between two groups was compared.ResuIts Compared with control group post-treatment, in experiment group, the blood pressure and 24 h urinary volume were higher, the respiratory rate and heart rate were lower (P<0.05);serum creatinine (Scr), blood urea nitrogen (BUN), and uric acid (UA) were lower (P<0.05);the T lymphocyte cell subsets of CD3 +, CD4 +and CD4 +/CD8 +was higher, the CD8 +T was lower ( P<0.05 ) .ConcIusion Reduning injection combined with blood purification has a good clinical curative effect in treatment of multiple organ failure in elderly patients, and could effectively improve the patient′s vital signs, renal function, regulate immune function, and improve vital signs, which has the vital significance to the clinical therapy.
