CAJ | 학술논문

目的：：通过球囊扩张兔左颈总动脉探讨兔动脉粥样硬化模型的建立及其评价。方法：48只家兔随机分为四组：普通饲料喂养组(12只)：普通饲料每天50 g/Kg，饲养10周；高脂组(12只)：普通饲料适应性饲养2周后，高脂饲料每天50 g/Kg喂养8周后处死；传统斑块模型组(12只)：普通饲料适应性饲养2周后，在直视下分离左侧颈总动脉，行球囊损伤术，然后结扎左颈总动脉远心端，术后再喂养8周后处死；改良斑块模型组(12只)：普通饲料适应性饲养2周后，在直视下分离左侧颈总动脉，行球囊损伤术，然后用7-0丝线缝合破口，术后再喂养8周后处死，观察实验前后血脂、颈动脉直径及其管壁形态变化。结果：与普通组相比，后三组均形成了高脂血症。改良组造影提示造模成功。改良组内膜厚度相对于传统组明显增厚，而中膜厚度明显变薄。结论：相对于传统造模方法，改良法没有破坏术侧的血流状态，能形成更为明显的动脉粥样硬化斑块。
목적：：통과구낭확장토좌경총동맥탐토토동맥죽양경화모형적건립급기평개。방법：48지가토수궤분위사조：보통사료위양조(12지)：보통사료매천50 g/Kg，사양10주；고지조(12지)：보통사료괄응성사양2주후，고지사료매천50 g/Kg위양8주후처사；전통반괴모형조(12지)：보통사료괄응성사양2주후，재직시하분리좌측경총동맥，행구낭손상술，연후결찰좌경총동맥원심단，술후재위양8주후처사；개량반괴모형조(12지)：보통사료괄응성사양2주후，재직시하분리좌측경총동맥，행구낭손상술，연후용7-0사선봉합파구，술후재위양8주후처사，관찰실험전후혈지、경동맥직경급기관벽형태변화。결과：여보통조상비，후삼조균형성료고지혈증。개량조조영제시조모성공。개량조내막후도상대우전통조명현증후，이중막후도명현변박。결론：상대우전통조모방법，개량법몰유파배술측적혈류상태，능형성경위명현적동맥죽양경화반괴。
Objective To establish and evaluate a modified athesclerotic plaque model in rabbits. Methods:Forty eight rabbits were randomly divided into four groups: Normal food group (No.12) : feeding with normal food 50 g/Kg for 10 weeks;High-fat group (No.12) : after 2 weeks of ordinary food for adaptatian, high-fat food 50 g/Kg for 8 weeks, then sacrificed. Traditional plague group (No.12) after ordinary food for adaptation 2 weeks,under direct vision,the left common carotid artery,was isolated,balloon injury and ligation were performed, after operation, feeding for 8 weeks then sacrified. Modified plaque model group (No.12): ordinary feeding 2 weeks,under the direct vision isolated the left common carotid artery, performed balloon injury,and then using 7-0 silk thread to suture the crevasse. feeding 8 weeks then sacrificed Blood lipid, the carotid artery diameter and morphological change were observed before and after the experiment. Results Compared with normal food group,hyperlipidemia were formed in the rest three groups. Angiography confrmed the success of the establisment of the modified model. Thickness of the intima was more obvious in improved group than in the traditional group,and the film thickness of tunica media was obviously thinner. Conclusion Compared with traditional building method,the improved method can form more obvious atherosclerotic plaque without damage to blood flow.