CAJ | 학술논문

目的：比较埃索美拉唑治疗老年人与中青年人胃溃疡的临床疗效及安全性。方法选取住院接受治疗的老年胃溃疡患者120例和中青年胃溃疡患者95例，两组均给予阿莫西林克拉维酸钾分散片0．457 g＋替硝唑片0．5 g＋埃索美拉唑镁肠溶片20mg口服，1次／d，治疗1周为1个疗程，1周后继续每天清晨空腹服用埃索美拉唑20 mg，1次／d，疗程为3周。比较两组临床疗效、Hp清除率及不良反应发生率。结果老年组总有效率（87．50％）与中青年组（92．63％）差异无统计学意义（χ2＝1．52，P＞0．05）。老年组Hp清除率（71．67％）与中青年组（76．84％）差异无统计学意义（χ2＝0．74，P＞0．05）。老年组不良反应发生率（8.33％）与中青年组（2．11％）差异有统计学意义（χ2＝3．90，P＜0．05）。结论应用埃索美拉唑为主的三联疗法在治疗老年人和中青年人胃溃疡的溃疡愈合及Hp根除方面都比较好，但是，中青年患者在不良反应方面低于老年组。
목적：비교애색미랍서치료노년인여중청년인위궤양적림상료효급안전성。방법선취주원접수치료적노년위궤양환자120례화중청년위궤양환자95례，량조균급여아막서림극랍유산갑분산편0．457 g＋체초서편0．5 g＋애색미랍서미장용편20mg구복，1차／d，치료1주위1개료정，1주후계속매천청신공복복용애색미랍서20 mg，1차／d，료정위3주。비교량조림상료효、Hp청제솔급불량반응발생솔。결과노년조총유효솔（87．50％）여중청년조（92．63％）차이무통계학의의（χ2＝1．52，P＞0．05）。노년조Hp청제솔（71．67％）여중청년조（76．84％）차이무통계학의의（χ2＝0．74，P＞0．05）。노년조불량반응발생솔（8.33％）여중청년조（2．11％）차이유통계학의의（χ2＝3．90，P＜0．05）。결론응용애색미랍서위주적삼련요법재치료노년인화중청년인위궤양적궤양유합급Hp근제방면도비교호，단시，중청년환자재불량반응방면저우노년조。
Objective To compare the clinical efficacy and safety of esomeprazole in treatment of elderly and young patients with gastric ulcer.Methods 120 cases of elderly patients with gastric ulcer and 95 cases of young and middle-aged patients with gastric ulcer were selected this study.Two groups of patients were treated with amoxicillin and clavulanate potassium dispersible tablets 0.457 g,tinidazole tablets 0.5 g and esomeprazole magnesium enteric coated tablets 20mg orally,once daily treatment 1 week for a course of treatment,1 week after continue to every morn-ing fasting taking esomeprazole 20mg,1 times/D,treatment for 3weeks.The clinical curative effect,Hp clearance rate and incidence of adverse reactions between two groups of patients after treatment were compared.Results The total effective rate in the treatment of elderly group patients (87.50%)compared with young and middle -aged group (92.63%),there was no significant difference (χ2 =1.52,P>1.52).Elderly group of patients with helicobacter pylori clearance rate (71.67%)compared with young and middle-aged group (76.84%),there was no significant difference (χ2 =0.74,P>0.74).The incidence of adverse reactions (8.33%)of elderly group had obvious differ-ences by comparing with young and middle -aged group (2.1 1%),and the difference was statistically significant (χ2 =3.90,P<0.05).Conclusion Application of esomeprazole based triple therapy in the treatment of the elderly and young people in the gastric ulcer could heal ulcers and eradicate Hp,but young and middle -aged patients is superior to the elderly group in terms of adverse reactions.