CAJ | 학술논문

目的：观察前列地尔加贝那普利联合丹芪汤加中药灌肠对糖尿病肾病蛋白尿的疗效。方法糖尿病肾病蛋白尿患者60例，按照随机数字表法随机分为对照组和治疗组，每组各30例。对照组给予静脉滴注前列地尔（0．2μg／mL，2次／天）加贝那普利片（10 mg，1次／天），治疗组在此基础上给予丹芪汤联合灌肠治疗（1次／天）。连续治疗3周后，检测2组治疗前后尿素氮、血肌酐、（24 h）尿蛋白（定量）、尿微白蛋白的排泄量变化。结果治疗3周后，对照组与治疗组的血肌酐、尿素氮、尿蛋白的化验检测值与尿微白蛋白排泄量与治疗前比较均有改善（P＜0．05）。治疗组的24 h尿蛋白（量）明显小于对照组（P＜0．05）；治疗组24 h尿微白蛋白排泄量也明显小于对照组（ P＜0．05）。结论前列地尔加贝那普利联合丹芪汤加中药灌肠治疗糖尿病肾病蛋白尿效果显著，能明显降低糖尿病肾病患者尿蛋白，减轻肾损伤。
목적：관찰전렬지이가패나보리연합단기탕가중약관장대당뇨병신병단백뇨적료효。방법당뇨병신병단백뇨환자60례，안조수궤수자표법수궤분위대조조화치료조，매조각30례。대조조급여정맥적주전렬지이（0．2μg／mL，2차／천）가패나보리편（10 mg，1차／천），치료조재차기출상급여단기탕연합관장치료（1차／천）。련속치료3주후，검측2조치료전후뇨소담、혈기항、（24 h）뇨단백（정량）、뇨미백단백적배설량변화。결과치료3주후，대조조여치료조적혈기항、뇨소담、뇨단백적화험검측치여뇨미백단백배설량여치료전비교균유개선（P＜0．05）。치료조적24 h뇨단백（량）명현소우대조조（P＜0．05）；치료조24 h뇨미백단백배설량야명현소우대조조（ P＜0．05）。결론전렬지이가패나보리연합단기탕가중약관장치료당뇨병신병단백뇨효과현저，능명현강저당뇨병신병환자뇨단백，감경신손상。
Objective To observe the clinical efficacy of alprostadil, benazepril combined with Danqi Decoction and herbal enema in treatment of diabetic renal proteinuria.Methods Sixty cases of diabetic renal proteinuria patients were randomly divided into the control group and the experimental group.Each group was 30 cases.The control group was given alprostadil(0.2μg/mL,2 times per day) and benazepril(10 mg,one time per day), while the experimental group was given Danqi Decoction combined with herbal enema on the basis of the control group(one time per day).The urea nitrogen, serum creatinine, quantitative of proteinuria (in 24 hours) and the excretion of urinary micro-albumin of both groups were all tested after three weeks of continuous treatment.ResuIts After three weeks of treatment, the laboratory values of urea nitrogen, serum creatinine, quantitative of proteinuria in 24 hours of both groups were all improved compared with those before treatment(P<0.05).Furthermore, the quantitative of proteinuria(in 24 hours) of the experimental group was significantly less than that of the control group(P<0.05), and the excretion of urinary micro-albumin of the experimental group was significantly less than that of the control group(P<0.05).ConcIusion The therapy of alprostadil, benazepril combined with Danqi Decoction and herbal enema is effective for diabetic renal proteinuria patients, and can significantly reduce proteinuria and renal injury.