中国生化药物杂志
中國生化藥物雜誌
중국생화약물잡지
CHINESE JOURNAL OF BIOCHEMICAL PHARMACEUTICS
2015年
8期
125-127
,共3页
连续性血液滤过%纳洛酮%多器官功能障碍综合征
連續性血液濾過%納洛酮%多器官功能障礙綜閤徵
련속성혈액려과%납락동%다기관공능장애종합정
continuous blood filtration%naloxone%multiple organ dysfunction syndrome
目的:探讨连续性血液滤过联合纳洛酮治疗儿科重症监护病房( pediatric intensive care unit ,PICU)多器官功能障碍综合征( multiple organ dysfunction syndrome ,MODS)的治疗效果及应用价值。方法选择郑州市儿童医院治疗的多器官功能障碍综合征患者42例作为研究对象,采取随机数字表法分为观察组和对照组,每组各21例,对照组采用PICH常规治疗,观察组在对照组基础上联合连续性血液滤过和纳洛酮治疗,比较2组患者生命体征、肌酐、肌酸激酶及天冬氨酸转氨酶水平以及住院时间与血液滤过使用时间。结果观察组患者治疗后1d和治疗后3d在心率、氧合指数、肌酐、肌酸激酶以及天冬氨酸转氨酶各项指标改善情况均优于对照组同一时间节点(P<0.05)。观察组连续性血液滤过使用时间和住院时间均短于对照组(P<0.05)。结论采用连续性血液滤过联合纳洛酮治疗PICU中MODS疗效可靠,明显改善患者肾脏功能,缩短患者住院时间,清除患者血浆中的炎症介质因子。
目的:探討連續性血液濾過聯閤納洛酮治療兒科重癥鑑護病房( pediatric intensive care unit ,PICU)多器官功能障礙綜閤徵( multiple organ dysfunction syndrome ,MODS)的治療效果及應用價值。方法選擇鄭州市兒童醫院治療的多器官功能障礙綜閤徵患者42例作為研究對象,採取隨機數字錶法分為觀察組和對照組,每組各21例,對照組採用PICH常規治療,觀察組在對照組基礎上聯閤連續性血液濾過和納洛酮治療,比較2組患者生命體徵、肌酐、肌痠激酶及天鼕氨痠轉氨酶水平以及住院時間與血液濾過使用時間。結果觀察組患者治療後1d和治療後3d在心率、氧閤指數、肌酐、肌痠激酶以及天鼕氨痠轉氨酶各項指標改善情況均優于對照組同一時間節點(P<0.05)。觀察組連續性血液濾過使用時間和住院時間均短于對照組(P<0.05)。結論採用連續性血液濾過聯閤納洛酮治療PICU中MODS療效可靠,明顯改善患者腎髒功能,縮短患者住院時間,清除患者血漿中的炎癥介質因子。
목적:탐토련속성혈액려과연합납락동치료인과중증감호병방( pediatric intensive care unit ,PICU)다기관공능장애종합정( multiple organ dysfunction syndrome ,MODS)적치료효과급응용개치。방법선택정주시인동의원치료적다기관공능장애종합정환자42례작위연구대상,채취수궤수자표법분위관찰조화대조조,매조각21례,대조조채용PICH상규치료,관찰조재대조조기출상연합련속성혈액려과화납락동치료,비교2조환자생명체정、기항、기산격매급천동안산전안매수평이급주원시간여혈액려과사용시간。결과관찰조환자치료후1d화치료후3d재심솔、양합지수、기항、기산격매이급천동안산전안매각항지표개선정황균우우대조조동일시간절점(P<0.05)。관찰조련속성혈액려과사용시간화주원시간균단우대조조(P<0.05)。결론채용련속성혈액려과연합납락동치료PICU중MODS료효가고,명현개선환자신장공능,축단환자주원시간,청제환자혈장중적염증개질인자。
Objective To investigate clinical effect of patients with PICU multiple organ dysfunction by continuous blood filtration combined with naloxone.Methods 42 patients with multiple organ function failure were selected and randomly divided into 2 groups.The control group were treated by PICU conventional therapy, the experiment group were treated by continuous blood filtration combined with Naloxone.Vital signs, creatinine, creatine kinase and aspartate aminotransferase levels, length of stay and blood filtration were compared after 1 day and 3 days treatment.ResuIts Compared with control group,heart rate, oxidation index,creatinine and aspartate aminotransferase levels of the experiment group were lower(P<0.05).After 1 day and 3 days, compared with cnontrol group, length of stay and blood filtration of the experiment were lower(P<0.05).ConcIusion Continuous blood filtration combined with naloxone in treatment of multiple organ dysfunction syndrome PICU is effective and reliable.It can significantly improve renal function, shorten the length of hospital stay, and remove inflammatory mediators in plasma of patients.