CAJ | 학술논문

目的：探讨连续性血液滤过联合纳洛酮治疗儿科重症监护病房（ pediatric intensive care unit ，PICU）多器官功能障碍综合征（ multiple organ dysfunction syndrome ，MODS）的治疗效果及应用价值。方法选择郑州市儿童医院治疗的多器官功能障碍综合征患者42例作为研究对象，采取随机数字表法分为观察组和对照组，每组各21例，对照组采用PICH常规治疗，观察组在对照组基础上联合连续性血液滤过和纳洛酮治疗，比较2组患者生命体征、肌酐、肌酸激酶及天冬氨酸转氨酶水平以及住院时间与血液滤过使用时间。结果观察组患者治疗后1d和治疗后3d在心率、氧合指数、肌酐、肌酸激酶以及天冬氨酸转氨酶各项指标改善情况均优于对照组同一时间节点（P＜0．05）。观察组连续性血液滤过使用时间和住院时间均短于对照组（P＜0．05）。结论采用连续性血液滤过联合纳洛酮治疗PICU中MODS疗效可靠，明显改善患者肾脏功能，缩短患者住院时间，清除患者血浆中的炎症介质因子。
목적：탐토련속성혈액려과연합납락동치료인과중증감호병방（ pediatric intensive care unit ，PICU）다기관공능장애종합정（ multiple organ dysfunction syndrome ，MODS）적치료효과급응용개치。방법선택정주시인동의원치료적다기관공능장애종합정환자42례작위연구대상，채취수궤수자표법분위관찰조화대조조，매조각21례，대조조채용PICH상규치료，관찰조재대조조기출상연합련속성혈액려과화납락동치료，비교2조환자생명체정、기항、기산격매급천동안산전안매수평이급주원시간여혈액려과사용시간。결과관찰조환자치료후1d화치료후3d재심솔、양합지수、기항、기산격매이급천동안산전안매각항지표개선정황균우우대조조동일시간절점（P＜0．05）。관찰조련속성혈액려과사용시간화주원시간균단우대조조（P＜0．05）。결론채용련속성혈액려과연합납락동치료PICU중MODS료효가고，명현개선환자신장공능，축단환자주원시간，청제환자혈장중적염증개질인자。
Objective To investigate clinical effect of patients with PICU multiple organ dysfunction by continuous blood filtration combined with naloxone.Methods 42 patients with multiple organ function failure were selected and randomly divided into 2 groups.The control group were treated by PICU conventional therapy, the experiment group were treated by continuous blood filtration combined with Naloxone.Vital signs, creatinine, creatine kinase and aspartate aminotransferase levels, length of stay and blood filtration were compared after 1 day and 3 days treatment.ResuIts Compared with control group,heart rate, oxidation index,creatinine and aspartate aminotransferase levels of the experiment group were lower(P<0.05).After 1 day and 3 days, compared with cnontrol group, length of stay and blood filtration of the experiment were lower(P<0.05).ConcIusion Continuous blood filtration combined with naloxone in treatment of multiple organ dysfunction syndrome PICU is effective and reliable.It can significantly improve renal function, shorten the length of hospital stay, and remove inflammatory mediators in plasma of patients.