中国生化药物杂志
中國生化藥物雜誌
중국생화약물잡지
CHINESE JOURNAL OF BIOCHEMICAL PHARMACEUTICS
2015年
8期
131-133
,共3页
帕米膦酸二钠%骨转移癌%骨痛%NTx
帕米膦痠二鈉%骨轉移癌%骨痛%NTx
파미련산이납%골전이암%골통%NTx
disodium pamidronate%bone metastasis cancer%bone pain%NTx
目的：探讨帕米膦酸二钠治疗骨转移癌患者的疗效。方法选取安阳市肿瘤医院骨转移癌患者50例，根据用药不同分为对照组和实验组，每组各25例，对照组按化疗方案给予化疗，实验组在对照组基础上给予帕米膦酸二钠45 mg＋0．9％氯化钠溶液500 mL，静脉滴注。治疗后对2组患者的止痛维持时间、患者疼痛分级以及血清Ⅰ型胶原交联氨基末端肽（ N－telopeptide of type Ⅰcollagen，NTx）水平进行检测。结果与对照组患者相比，实验组止痛持续时间较长（ P＜0．05），疼痛水平总体较低，NTx水平较低（P＜0．05）。结论帕米膦酸二钠能够明显抑制骨转移癌患者的骨痛程度，降低血清NTx水平。
目的：探討帕米膦痠二鈉治療骨轉移癌患者的療效。方法選取安暘市腫瘤醫院骨轉移癌患者50例，根據用藥不同分為對照組和實驗組，每組各25例，對照組按化療方案給予化療，實驗組在對照組基礎上給予帕米膦痠二鈉45 mg＋0．9％氯化鈉溶液500 mL，靜脈滴註。治療後對2組患者的止痛維持時間、患者疼痛分級以及血清Ⅰ型膠原交聯氨基末耑肽（ N－telopeptide of type Ⅰcollagen，NTx）水平進行檢測。結果與對照組患者相比，實驗組止痛持續時間較長（ P＜0．05），疼痛水平總體較低，NTx水平較低（P＜0．05）。結論帕米膦痠二鈉能夠明顯抑製骨轉移癌患者的骨痛程度，降低血清NTx水平。
목적：탐토파미련산이납치료골전이암환자적료효。방법선취안양시종류의원골전이암환자50례，근거용약불동분위대조조화실험조，매조각25례，대조조안화료방안급여화료，실험조재대조조기출상급여파미련산이납45 mg＋0．9％록화납용액500 mL，정맥적주。치료후대2조환자적지통유지시간、환자동통분급이급혈청Ⅰ형효원교련안기말단태（ N－telopeptide of type Ⅰcollagen，NTx）수평진행검측。결과여대조조환자상비，실험조지통지속시간교장（ P＜0．05），동통수평총체교저，NTx수평교저（P＜0．05）。결론파미련산이납능구명현억제골전이암환자적골통정도，강저혈청NTx수평。
Objective To investigate the efficacy of disodium pamidronate in treatment of bone metastasis cancer .Methods 50 cases of bone metastasis cancer were divided into control group and experimental group according to different medication, 25 cases in each group.Control group was treated by chemotherapy, experimental group was treated on the basis of control group with disodium pamidronate 45 mg+0.9%sodium chloride solution 500 mL, intravenous drip.Pain maintenance time, patient pain grading and serum NTx levels were compared after treatment.ResuIts Compared with control group,pain maintenance time of experimental group was longer(P <0.05),pain level overall score was lower,NTx was lower(P <0.05). ConcIusion Disodium pamidronate can inhibit bone metastasis cancer patients with the degree of pain, reduce the levels of serum NTx.
