CAJ | 학술논문

目的：对具有自主知识产权的抗栓小肽RWR进行毒理学研究和安全性评价。方法分别对RWR进行小鼠急性毒性试验、小鼠骨髓细胞微核形成试验、小鼠精子畸形试验和大鼠30d喂养试验。结果急性毒性试验动物经腹腔注射MTD大于120 mg／kg；骨髓细胞微核试验、精子畸形试验结果均为阴性；大鼠30 d喂养试验对大鼠体质量、食物利用率、脏器系数、血生化等各项指标均未见不良影响。病理组织学观察肺、肝、脾、肾、心脏均未见明显与注射样品有关的组织学病理改变。结论在本试验条件下， RWR对动物的生长发育、造血功能、肝肾功能、器官组织均无明显毒性作用。
목적：대구유자주지식산권적항전소태RWR진행독이학연구화안전성평개。방법분별대RWR진행소서급성독성시험、소서골수세포미핵형성시험、소서정자기형시험화대서30d위양시험。결과급성독성시험동물경복강주사MTD대우120 mg／kg；골수세포미핵시험、정자기형시험결과균위음성；대서30 d위양시험대대서체질량、식물이용솔、장기계수、혈생화등각항지표균미견불량영향。병리조직학관찰폐、간、비、신、심장균미견명현여주사양품유관적조직학병리개변。결론재본시험조건하， RWR대동물적생장발육、조혈공능、간신공능、기관조직균무명현독성작용。
Objective To evaluate the toxicological safety of antithrombotic small peptide RWR with independent intellectual property right. Methods Toxicity test in mice, mice bone marrow micronucleus assay, mice sperm abnormality test, and 30-day feeding test in rats were carried out in this study.ResuIts The MTD of acute toxicity test for rats was larger than 120 mg/kg.The results of bone marrow micronucleus assay, mice sperm abnormality test were all negative.Thirty-day feeding test had no adverse effects on body weight, food utility rate, organ coefficient, blood routine index of rats.There was also no histological changes related to RWR in lung, liver, spleen, kidney and heart of rats.ConcIusion RWR had no obvious toxicity on animal growth, hematopoietic function, kidney function and organ tissue and so on.