中国生化药物杂志
中國生化藥物雜誌
중국생화약물잡지
CHINESE JOURNAL OF BIOCHEMICAL PHARMACEUTICS
2015年
8期
140-142,145
,共4页
谭伟%宋永红%孙雪文%齐庆彬
譚偉%宋永紅%孫雪文%齊慶彬
담위%송영홍%손설문%제경빈
药用炭片%血液净化%严重腹腔感染%肾功能%炎性介质%氧合指数%肠屏障功能
藥用炭片%血液淨化%嚴重腹腔感染%腎功能%炎性介質%氧閤指數%腸屏障功能
약용탄편%혈액정화%엄중복강감염%신공능%염성개질%양합지수%장병장공능
medicinal charcoal tablets%blood purification%severe abdominal infection%renal function%inflammatory mediators%oxygenation index%intestinal barrier function
目的：探讨药用炭片联合血液净化治疗对重症腹腔感染术后患者肾功能、炎性介质、氧合指数（ oxygenation index ，OI）及肠屏障功能的影响。方法选取河北工程大学附属医院诊治的重症腹腔感染患者65例，根据随机数字表法随机分为2组：对照组32例临床常规治疗；实验组33例，在对照组基础上联合应用药用炭片联合血液净化治疗，检测2组患者的肾脏功能、炎性介质、OI、肠屏障功能及疗效。结果治疗后，与对照组比较，实验组血肌酐（serum creatinine，Scr）、尿素氮（blood urea nitrogen，BUM）及血尿酸（uric acid，UA）等肾功能指标水平较低（P＜0．05）；实验组肿瘤坏死因子－α（tumor necrosis factor alpha，TNF－α）、白介素－6（interleukin－6，IL－6）、白介素－8（interleukin－8，IL－8）等炎性介质浓度水平较低（P＜0．05）；实验组氧合指数水平较高（P＜0．05）；实验组血浆二胺氧化酶（diamine oxidase，DAO）和内毒素脂多糖（lipopolysaccharide，LPS）等肠屏障功能指标水平较低（P＜0．05）；实验组总有效率较高（χ2＝3．91，P＜0．05）。结论药用炭片联合血液净化能有效改善患者肾脏功能，降低炎性介质水平，改善肠屏障功能，提高氧合指数水平，对严重腹腔感染患者有较好的临床疗效。
目的：探討藥用炭片聯閤血液淨化治療對重癥腹腔感染術後患者腎功能、炎性介質、氧閤指數（ oxygenation index ，OI）及腸屏障功能的影響。方法選取河北工程大學附屬醫院診治的重癥腹腔感染患者65例，根據隨機數字錶法隨機分為2組：對照組32例臨床常規治療；實驗組33例，在對照組基礎上聯閤應用藥用炭片聯閤血液淨化治療，檢測2組患者的腎髒功能、炎性介質、OI、腸屏障功能及療效。結果治療後，與對照組比較，實驗組血肌酐（serum creatinine，Scr）、尿素氮（blood urea nitrogen，BUM）及血尿痠（uric acid，UA）等腎功能指標水平較低（P＜0．05）；實驗組腫瘤壞死因子－α（tumor necrosis factor alpha，TNF－α）、白介素－6（interleukin－6，IL－6）、白介素－8（interleukin－8，IL－8）等炎性介質濃度水平較低（P＜0．05）；實驗組氧閤指數水平較高（P＜0．05）；實驗組血漿二胺氧化酶（diamine oxidase，DAO）和內毒素脂多糖（lipopolysaccharide，LPS）等腸屏障功能指標水平較低（P＜0．05）；實驗組總有效率較高（χ2＝3．91，P＜0．05）。結論藥用炭片聯閤血液淨化能有效改善患者腎髒功能，降低炎性介質水平，改善腸屏障功能，提高氧閤指數水平，對嚴重腹腔感染患者有較好的臨床療效。
목적：탐토약용탄편연합혈액정화치료대중증복강감염술후환자신공능、염성개질、양합지수（ oxygenation index ，OI）급장병장공능적영향。방법선취하북공정대학부속의원진치적중증복강감염환자65례，근거수궤수자표법수궤분위2조：대조조32례림상상규치료；실험조33례，재대조조기출상연합응용약용탄편연합혈액정화치료，검측2조환자적신장공능、염성개질、OI、장병장공능급료효。결과치료후，여대조조비교，실험조혈기항（serum creatinine，Scr）、뇨소담（blood urea nitrogen，BUM）급혈뇨산（uric acid，UA）등신공능지표수평교저（P＜0．05）；실험조종류배사인자－α（tumor necrosis factor alpha，TNF－α）、백개소－6（interleukin－6，IL－6）、백개소－8（interleukin－8，IL－8）등염성개질농도수평교저（P＜0．05）；실험조양합지수수평교고（P＜0．05）；실험조혈장이알양화매（diamine oxidase，DAO）화내독소지다당（lipopolysaccharide，LPS）등장병장공능지표수평교저（P＜0．05）；실험조총유효솔교고（χ2＝3．91，P＜0．05）。결론약용탄편연합혈액정화능유효개선환자신장공능，강저염성개질수평，개선장병장공능，제고양합지수수평，대엄중복강감염환자유교호적림상료효。
Objective To investigate the effect of medicinal charcoal tablets combined with blood purification therapy on on renal function, inflammatory mediators, oxygenation index and intestinal barrier function in patients postoperative severe abdominal infection.Methods 65 cases with severe abdominal infection from the hospital were selected and randomly divided into control group (32 cases) and experiment group (33 cases) by random digital table method.The control group were treated by clinical routine therapy and experiment group were treated on the basis of control group with medicinal charcoal tablets combined with blood purification therapy.The renal function, inflammatory mediators, oxygenation index, intestinal barrier function and efficacy were tested.ResuIts Compared with control group after treatment, the renal function of serum creatinine (Scr), blood urea nitrogen (BUM), uric acid (UA) levels were lower (P<0.05), the inflammatory mediators of tumor necrosis factor α(TNF-α), interleukin-6 (IL-6) and interleukin-8 (IL-8) levels were lower (P<0.05), the oxygenation index (OI) was higher(P<0.05), the intestinal barrier function indicators of plasma diamine oxidase (DAO) and endotoxin of lipopolysaccharide (LPS) were lower (P<0.05), the total efficiency were higher (χ2 =3.91, P<0.05) in experimental group.ConcIusion The medicinal charcoal tablets combined with blood purification could effectively improve renal function, reduce inflammatory mediators levels, improve intestinal barrier function, and increase oxygenation index in patients with severe abdominal infection, which has a good clinical curative effect for postoperative severe abdominal infection .
