CAJ | 학술논문

目的：探讨瑞格列奈联合珍芪降糖胶囊对老年2型糖尿病患者β细胞功能的影响。方法收集海口市人民医院海港分院收治老年2型糖尿病患者60例，随机分为实验组和对照组，每组各30例。2组患者均给予控制饮食、适度运动等常规辅助治疗。对照组在此基础上给予瑞格列奈1 mg／次，1天3次，口服治疗；实验组在对照组基础上给予珍芪降糖胶囊4粒／次，1天3次，口服治疗，共治疗4周。治疗结束后，对所有患者的血糖水平、血清胰岛素水平、β细胞功能相关指数以及血脂情况进行检测。结果治疗后，与对照组比较，实验组患者餐后各时段血糖水平、HbA1c水平及AUCg含量明显较低（P＜0．05）；实验组患者餐后30、60、120 min胰岛素水平均明显较高（P＜0．05）；实验组患者的HOMA－IR明显较低（P＜0．05）；实验组患者的IRG、AUCi、AUCi／AUCg明显较高（P＜0．05）；实验组患者的血清TC、TG、LDL水平均明显较低，血清HDL水平明显较高（P＜0．05）。结论瑞格列奈联合珍芪降糖颗粒能够明显降低老年2型糖尿病患者的血糖、血脂水平，提高胰岛β细胞的功能，促进餐后胰岛素分泌，改善胰岛素抵抗。
목적：탐토서격렬내연합진기강당효낭대노년2형당뇨병환자β세포공능적영향。방법수집해구시인민의원해항분원수치노년2형당뇨병환자60례，수궤분위실험조화대조조，매조각30례。2조환자균급여공제음식、괄도운동등상규보조치료。대조조재차기출상급여서격렬내1 mg／차，1천3차，구복치료；실험조재대조조기출상급여진기강당효낭4립／차，1천3차，구복치료，공치료4주。치료결속후，대소유환자적혈당수평、혈청이도소수평、β세포공능상관지수이급혈지정황진행검측。결과치료후，여대조조비교，실험조환자찬후각시단혈당수평、HbA1c수평급AUCg함량명현교저（P＜0．05）；실험조환자찬후30、60、120 min이도소수평균명현교고（P＜0．05）；실험조환자적HOMA－IR명현교저（P＜0．05）；실험조환자적IRG、AUCi、AUCi／AUCg명현교고（P＜0．05）；실험조환자적혈청TC、TG、LDL수평균명현교저，혈청HDL수평명현교고（P＜0．05）。결론서격렬내연합진기강당과립능구명현강저노년2형당뇨병환자적혈당、혈지수평，제고이도β세포적공능，촉진찬후이도소분비，개선이도소저항。
Objective To analyse the effect of repaglinide combined with Zhenqi Jiangtang Capsules on βcell function in elderly patients with type 2 diabetes mellitus.Methods 60 elderly patients were collected from harbour branch of Hainan provincial People's hospital, who were diagnosed with type 2 diabetes mellitus .All patients were randomly divided into experimental group and control group, 30 cases in each group, 2 groups of patients were given control diet, moderate exercise, and other conventional adjuvant therapy.Control group was treated with repaglinide orally on the basis of routine adjuvant treatment, 1 mg/times, three times per day,experimental group were given Zhenqi Jiangtang Capsules based on the treatment in control group,4 grains/times,three times per day.Both groups were treated for 4 weeks, after the end of treatment, blood glucose levels,serum insulin levels,βcell function and serum lipids in all patients were detected.ResuIts After treatment, compared with control group, the levels of blood glucose, HbA1c and AUCg in experimental group were significantly lower ( P<0.05 );the insulin levels 30 min,60 min, 120 min after meal were significantly higher (P<0.05);the HOMA-IR of patients was significantly lower(P<0.05);IRG, AUCi and AUCi/AUCg were significantly higher (P<0.05);the serum TC, TG, LDL levels were significantly lower, serum HDL levels were significantly higher(P<0.05).ConcIusion Repaglinide combined with Zhenqi Jiangtang Capsules can significantly reduce the blood glucose and lipid levels in elderly patients with type 2 diabetes, improve the function of pancreatic beta cells, promote postprandial insulin secretion and improve insulin resistance.