CAJ | 학술논문

目的：探讨并分析普拉克索治疗帕金森病合并抑郁的临床疗效。方法选取帕金森病合并抑郁患者共100例作为研究对象，采用数字表法随机分成两组，其中观察组与对照组各50例，对照组采取常规治疗方法，观察组采取在常规治疗方法的基础上给予普拉克索治疗，治疗后，收集两组病例治疗前后的Hamil-ton抑郁量表（HAMD）和统一帕金森病评分量表（UPDRS）评分。结果观察组治疗后12周 HAMD 评分（8.26±1．96）分，明显低于治疗前的（24．91±4．6）分（P＜0．05），对照组治疗后12周HAMD评分（11．15±2.10）分，与治疗前的（24．48±5．34）分差异有统计学意义（P＜0．05）；治疗后12周观察组的HAMDP评分显著低于对照组，两组有效率分别为94％、80％，差异有统计学意义（P＜0．05）。两组治疗后UPDRS评分明显低于治疗前（χ2＝14．756，P＜0．05）。结论普拉克索治疗帕金森病伴抑郁患者有效，可明显改善患者的运动症状，具有推广价值。
목적：탐토병분석보랍극색치료파금삼병합병억욱적림상료효。방법선취파금삼병합병억욱환자공100례작위연구대상，채용수자표법수궤분성량조，기중관찰조여대조조각50례，대조조채취상규치료방법，관찰조채취재상규치료방법적기출상급여보랍극색치료，치료후，수집량조병례치료전후적Hamil-ton억욱량표（HAMD）화통일파금삼병평분량표（UPDRS）평분。결과관찰조치료후12주 HAMD 평분（8.26±1．96）분，명현저우치료전적（24．91±4．6）분（P＜0．05），대조조치료후12주HAMD평분（11．15±2.10）분，여치료전적（24．48±5．34）분차이유통계학의의（P＜0．05）；치료후12주관찰조적HAMDP평분현저저우대조조，량조유효솔분별위94％、80％，차이유통계학의의（P＜0．05）。량조치료후UPDRS평분명현저우치료전（χ2＝14．756，P＜0．05）。결론보랍극색치료파금삼병반억욱환자유효，가명현개선환자적운동증상，구유추엄개치。
Objective To investigate and analysis the clinical effect of pramipexole in Parkinson's disease with depression.Methods The patients with Parkinson disease patients with depression were selected in a total of 100 as the research object,and were randomly divided into two groups,the observation group and the control group with 50 cases in each group.The control group was taken conventional treatment,the observation group was given pramipexole based on the conventional treatment methods,the the effects of treatment were observed and compared. Results The MIHD score of the observation group after treated for 12 month (8.26 ±1.96)was lower than the score before treatment (24.91 ±4.6),and the score of the control group after treated for 12 month (11.15 ±2.10)was also lower than the score before treatment (24.48 ±5.34),the difference were all statistically significant(P<0.05). After treated for 12 month,the score in the observation group was lower than that in the control group,and the total effective rate in the two group were 94% and 80% respectively(P<0.05 ).The UPDRS score of the observation group was lower than in the control group,but the difference was not significant(χ2 =14.756,P<0.05).Conclusion Give pramipexole has notable curative effect on the depression disease in patients with Parkinson disease on the basis of conventional therapy method,and has the value of popularization.