药学研究
藥學研究
약학연구
JOURNAL OF PHARMACEUTICAL RESEARCH
2015年
9期
553-555
,共3页
伊曲茶碱%抗帕金森药%合成
伊麯茶堿%抗帕金森藥%閤成
이곡다감%항파금삼약%합성
Istradefylline%AntiparKinsonian%Agent synthesis
以碳酸二甲酯、藜芦醛为起始原料，经过亚硝化、还原、上侧链、甲基化等反应工序，制备得到目标产物伊曲茶碱，工艺稳定、环境友好，且收率高、成本低具有广阔的市场前景。
以碳痠二甲酯、藜蘆醛為起始原料，經過亞硝化、還原、上側鏈、甲基化等反應工序，製備得到目標產物伊麯茶堿，工藝穩定、環境友好，且收率高、成本低具有廣闊的市場前景。
이탄산이갑지、려호철위기시원료，경과아초화、환원、상측련、갑기화등반응공서，제비득도목표산물이곡다감，공예은정、배경우호，차수솔고、성본저구유엄활적시장전경。
Istradefylline was synthesized from ethamine and methyl - carbonate by condensation,cyclization,nitrosation and reduction,followed by cyclization and methylation. This technology had process stability,environment friendly,high yield, low cost,and broad marKet prospects.
