CAJ | 학술논문

目的：构建以及分析评价膳食诱导的自发性高血压痰湿壅盛型大鼠动物模型。方法体重180～200 g雄性 Wistar 大鼠分为普通膳食对照组、高脂膳食组、高脂高盐膳食组、高脂高糖膳食组（每组10只），分别给予普通膳食、高脂饲料、高脂高盐饲料和高脂高糖饲料。然后每2～4周观测1次体重、血压和血糖，16周后测定空腹胰岛素并观测血脂、血糖。结果高脂高盐模型组的体重、血糖、甘油三酯、胰岛素抵抗比对照组均有显著性差异，血压普遍升高。结论高脂高盐饮食诱导建立痰湿壅盛型高血压大鼠动物模型，符合中医痰湿壅盛型高血压的辨证分型特点，成模率较高。
목적：구건이급분석평개선식유도적자발성고혈압담습옹성형대서동물모형。방법체중180～200 g웅성 Wistar 대서분위보통선식대조조、고지선식조、고지고염선식조、고지고당선식조（매조10지），분별급여보통선식、고지사료、고지고염사료화고지고당사료。연후매2～4주관측1차체중、혈압화혈당，16주후측정공복이도소병관측혈지、혈당。결과고지고염모형조적체중、혈당、감유삼지、이도소저항비대조조균유현저성차이，혈압보편승고。결론고지고염음식유도건립담습옹성형고혈압대서동물모형，부합중의담습옹성형고혈압적변증분형특점，성모솔교고。
Objective To establish and evaluate a rat model of dampness hypertension. Methods Wistar rats,180 ~200 g,were divided into routine diet control group,high fat group,high fat and salt diet group,high fat and sugar diet group, 10 animals in each group. Then the body weights,blood pressure and blood glucose were measured every 2 ~ 4 weeKs. 16 weeKs later,trypsin with empty stomach was determined,blood fat and blood sugar were observed. Results In the model group which was given high fat and salt diet,the body weight,visceral fat,blood pressure,insulin and triglycerol levels were all significantly increased comparing with control group,and significant insulin resistance occurred. Conclusion High fat and salt diet could induce a dampness hypertension model,which corresponded to the syndromes characteristic of dampness hypertension,and the rate of modeling was higher.