CAJ | 학술논문

目的：探讨盐酸伊立替康注射液对直肠癌晚期患者血清谷胱甘肽过氧化物酶3（glutathione peroxidase 3，GPX3）、肿瘤组织液中WNT1诱导信号通道蛋白2（ WNT1 inducible signaling pathway protein 2，WISP2）及成纤维细胞生长因子结合蛋白1（ fibroblast growth factor binding protein 1，FGFBP1）的影响。方法选取郑州大学附属肿瘤医院已确诊为晚期直肠癌患者90例，随机分为实验组和对照组，对照组给予奥沙利铂＋亚叶酸钙＋氟尿嘧啶化疗方案，实验组给予奥沙利铂＋亚叶酸钙＋盐酸伊立替康化疗方案，每4周重复1次，共6次。治疗前后分别检测2组患者的血清GPX3蛋白含量、肿瘤组织液WISP2、FGFBP1蛋白水平，评价临床疗效。结果与对照组比较，实验组患者血清GPX3蛋白含量明显升高（P＜0．05）；肿瘤组织液WISP2蛋白水平显著升高（P＜0．05）；肿瘤组织液FGFBP1蛋白水平显著降低（P＜0．05）；实验组的总有效率为明显高于对照组（64．44％vs．42．22％；χ2＝4．46，P＜0．05），实验组的临床获益率明显高于对照组（93．33％ vs．75．56％；χ2＝5．41，P＜0．05）。结论盐酸伊立替康注射液能够使直肠癌晚期患者血清WISP2、肿瘤组织液GPX3表达水平升高，肿瘤组织液FGFBP1表达水平降低，具有良好的临床疗效。
목적：탐토염산이립체강주사액대직장암만기환자혈청곡광감태과양화물매3（glutathione peroxidase 3，GPX3）、종류조직액중WNT1유도신호통도단백2（ WNT1 inducible signaling pathway protein 2，WISP2）급성섬유세포생장인자결합단백1（ fibroblast growth factor binding protein 1，FGFBP1）적영향。방법선취정주대학부속종류의원이학진위만기직장암환자90례，수궤분위실험조화대조조，대조조급여오사리박＋아협산개＋불뇨밀정화료방안，실험조급여오사리박＋아협산개＋염산이립체강화료방안，매4주중복1차，공6차。치료전후분별검측2조환자적혈청GPX3단백함량、종류조직액WISP2、FGFBP1단백수평，평개림상료효。결과여대조조비교，실험조환자혈청GPX3단백함량명현승고（P＜0．05）；종류조직액WISP2단백수평현저승고（P＜0．05）；종류조직액FGFBP1단백수평현저강저（P＜0．05）；실험조적총유효솔위명현고우대조조（64．44％vs．42．22％；χ2＝4．46，P＜0．05），실험조적림상획익솔명현고우대조조（93．33％ vs．75．56％；χ2＝5．41，P＜0．05）。결론염산이립체강주사액능구사직장암만기환자혈청WISP2、종류조직액GPX3표체수평승고，종류조직액FGFBP1표체수평강저，구유량호적림상료효。
Objective To analyse the effect of irinotecan hydrochloride injection on serum glutathione peroxidase 3 (GPX3), and WNT1 induced signaling pathway protein 2 (WISP2) and fibroblast growth factor binding protein 1 (FGFBP1) in tumor tissue fluid of patients with advanced rectal cancer.Methods 90 patients who were diagnosed with advanced rectal cancer in the hospital were collected.All patients were randomly divided into experimental group and control group,control group were treated with oxaliplatin +calcium folinate +fluorouracil chemotherapy, and experimental group were treated with oxaliplatin +calcium folinate +irinotecan hydrochloride injection chemotherapy.The treatment were repeated every four weeks, a total of six times.The serum GPX3 content, and WISP2, FGFBP1 levels in tumor tissue fluid were detected in two groups pre-and post treatment.The clinical efficacy was evaluated.ResuIts Compared with control group, the serum level of GPX3 in experimental group increased significantly (P<0.05);WISP2 level in tumor tissue fluid of experimental group increased significantly (P<0.05);FGFBP1 level in tumor tissue fluid of experimental group decreased significantly ( P<0.05 ) .The total efficiency of experimental group was higher than that of control group ( 64.44%vs.42.22%;χ2 =4.46,P<0.05), and the clinical benefit rate of experimental group was significantly higher than that of control group(93.33%vs.75.56%;χ2 =5.41,P<0.05).ConcIusion The irinotecan hydrochloride injection could increased levels of serum GPX3 and WISP2 in tumor tissue fluid, reduce FGFBP1 level in tumor tissue fluid, which has good clinical curative effect.