中国生化药物杂志
中國生化藥物雜誌
중국생화약물잡지
CHINESE JOURNAL OF BIOCHEMICAL PHARMACEUTICS
2015年
8期
110-112,115
,共4页
沙丁胺醇气雾剂%硫酸镁%小儿哮喘%T淋巴细胞亚群%IL-2%IL-4%IL-5%IFN-γ
沙丁胺醇氣霧劑%硫痠鎂%小兒哮喘%T淋巴細胞亞群%IL-2%IL-4%IL-5%IFN-γ
사정알순기무제%류산미%소인효천%T림파세포아군%IL-2%IL-4%IL-5%IFN-γ
salbutamol aerosol%magnesium sulfate%pediatric asthma%T lymphocyte subsets%IL-2%IL-4%IL-5%IFN-γ
目的:探讨沙丁胺醇气雾剂联合硫酸镁对小儿哮喘IL-2、IL-4、IL-5、IFN-γ及T淋巴细胞亚群的影响。方法选取已确诊为哮喘的患儿38例,采用随机数字表法将患者随机分为实验组和对照组,对照组予临床常规方法治疗,实验组采用沙丁胺醇气雾剂联合硫酸镁治疗,疗程1周。观察2组患者IL-2、IL-4、IL-5、IFN-γ、T淋巴细胞亚群、血压、心率、呼吸和临床疗效。结果与对照组相比,实验组患者血清IL-2、IFN-γ水平较高(P<0.05),IL-4、IL-5水平较低(P<0.05);实验组CD3+、CD4+、CD4+/CD8+水平较高(P<0.05),血清CD8+较低(P<0.05),实验组总有效率较高(P<0.05)。结论沙丁胺醇气雾剂联合硫酸镁能有效调节哮喘患儿T淋巴细胞亚群比例和细胞因子水平,提高免疫力,改善临床症状。
目的:探討沙丁胺醇氣霧劑聯閤硫痠鎂對小兒哮喘IL-2、IL-4、IL-5、IFN-γ及T淋巴細胞亞群的影響。方法選取已確診為哮喘的患兒38例,採用隨機數字錶法將患者隨機分為實驗組和對照組,對照組予臨床常規方法治療,實驗組採用沙丁胺醇氣霧劑聯閤硫痠鎂治療,療程1週。觀察2組患者IL-2、IL-4、IL-5、IFN-γ、T淋巴細胞亞群、血壓、心率、呼吸和臨床療效。結果與對照組相比,實驗組患者血清IL-2、IFN-γ水平較高(P<0.05),IL-4、IL-5水平較低(P<0.05);實驗組CD3+、CD4+、CD4+/CD8+水平較高(P<0.05),血清CD8+較低(P<0.05),實驗組總有效率較高(P<0.05)。結論沙丁胺醇氣霧劑聯閤硫痠鎂能有效調節哮喘患兒T淋巴細胞亞群比例和細胞因子水平,提高免疫力,改善臨床癥狀。
목적:탐토사정알순기무제연합류산미대소인효천IL-2、IL-4、IL-5、IFN-γ급T림파세포아군적영향。방법선취이학진위효천적환인38례,채용수궤수자표법장환자수궤분위실험조화대조조,대조조여림상상규방법치료,실험조채용사정알순기무제연합류산미치료,료정1주。관찰2조환자IL-2、IL-4、IL-5、IFN-γ、T림파세포아군、혈압、심솔、호흡화림상료효。결과여대조조상비,실험조환자혈청IL-2、IFN-γ수평교고(P<0.05),IL-4、IL-5수평교저(P<0.05);실험조CD3+、CD4+、CD4+/CD8+수평교고(P<0.05),혈청CD8+교저(P<0.05),실험조총유효솔교고(P<0.05)。결론사정알순기무제연합류산미능유효조절효천환인T림파세포아군비례화세포인자수평,제고면역력,개선림상증상。
Objective To investigate the effect of salbutamol aerosol combined with magnesium sulfate on IL-2, IL-4, IL-5, IFN-γand T lymphocyte subsets in pediatric asthma patients.Methods 38 pediatric asthma patients were selected and randomly divided into control group and experimental group.Control group was treated by clinical routine method.Experimental group was treated by salbutamol aerosol combined with magnesium sulfate.The IL-2, IL-4, IL-5, IFN-γ, T lymphocyte subsets, blood pressure, heart rate, respiratory and clinical effects were observed and compared.ResuIts Compared with control group, the serum levels of IL-2 and IFN-γwere higher(P<0.05).The IL-5, IL-4 level were lower(P<0.05).The CD3 +, CD4 +, CD4 +/CD8 +level were higher(P<0.05).The serum CD8 +were lower(P<0.05).The total efficiency were higher(P<0.05).ConcIusion Salbutamol aerosol combined with magnesium sulfate can effectively regulate T lymphocyte subsets proportion and cytokine levels in asthmatic children, enhance immunity, and improve the clinical symptoms.