CAJ | 학술논문

目的：探讨胆囊摘除术后患者白介素6、白介素10以及TNF－α水平变化。方法收集胆囊结石需行胆囊切除术患者46例，根据手术术式不同分为实验组和对照组，每组各23例。对照组患者行开腹手术，实验组患者给予腹腔镜胆囊切除术。比较2组患者治疗前后IL－6、IL－10、TNF－α水平以及CD4＋／CD8＋T进行检测。结果与手术前比较，2组患者IL－6、IL－10、TNF－α及CD4＋T与CD4＋／CD8＋T上升（P＜0．05），与对照组比较，实验组IL－6、IL－10、TNF－α水平较低，CD4＋／CD8＋T水平较高（P＜0．05）。结论腹腔镜胆囊切除术能够明显减缓IL－6、IL－10以及TNF－α水平的升高，降低机体对手术的应激反应，并且减少手术中血流量，缩短手术时间。
목적：탐토담낭적제술후환자백개소6、백개소10이급TNF－α수평변화。방법수집담낭결석수행담낭절제술환자46례，근거수술술식불동분위실험조화대조조，매조각23례。대조조환자행개복수술，실험조환자급여복강경담낭절제술。비교2조환자치료전후IL－6、IL－10、TNF－α수평이급CD4＋／CD8＋T진행검측。결과여수술전비교，2조환자IL－6、IL－10、TNF－α급CD4＋T여CD4＋／CD8＋T상승（P＜0．05），여대조조비교，실험조IL－6、IL－10、TNF－α수평교저，CD4＋／CD8＋T수평교고（P＜0．05）。결론복강경담낭절제술능구명현감완IL－6、IL－10이급TNF－α수평적승고，강저궤체대수술적응격반응，병차감소수술중혈류량，축단수술시간。
Objective To investigate the changes of IL-6, IL-10 and TNF-αafter cholecystectomy.Methods 46 cases with cholecystolithiasis were selected and divided into 2 groups.23 in control group were treated with open cholecystectomy, experimental group were treated with laparoscopic cholecystectomy.The levels of IL-6, TNF-α, IL-10 and CD4 +/CD8 +T were compared in the two groups pre-and post-treatment.ResuIts Compared with pre-treatment, two groups of patients with IL-10, TNF-α, IL-6 and CD4 +T and CD4 +/CD8 +T increased (P<0.05), compared with control group, experimental group IL-10, TNF-α, IL-6, CD4 +/CD8 +T levels were higher (P<0.05).ConcIusion Laparoscopic cholecystectomy can significantly reduce the IL-6, TNF-αand IL-10 levels, reduce the body′s stress response to surgery, and reduce blood flow, shorten the operation time.